赵运英
赵运英
职称：副教授、硕士生导师
学历/学位：研究生/博士
电话：15251637269
电子邮箱：yunyingzhao@jiangnan.edu.cn
从事酿酒酵母和大肠杆菌等微生物代谢工程和合成生物学方面的研究，主要承担《分子生物学实验》和《细胞生物学》等课程的讲授工作。近年来，发表SCI论文20余篇，申请发明专利10余项；主持和参与多项国家重点研发计划、国家自然基金、江苏省自然科学基金等省部级以上科研项目。
工作经历
2019.6-至今江南大学，粮食发酵工艺与技术国家工程实验室，副教授
2014.2-2016.11江南大学生物工程学院，在职博士后
2013.1-2019.5江南大学，粮食发酵工艺与技术国家工程实验室，讲师
学习经历
2009.9-2013.1天津大学，药物科学与技术学院，生物分子工程专业，工学博士
2006.9-2009.7南开大学，生命科学学院，生物化学与分子生物学专业，理学硕士
2002.9-2006.7曲阜师范大学，生命科学学院，生物技术专业，理学学士
一、论文（论著）发表情况
部分代表性论文如下：
1.Shiyun Li, Wenxuan Fu, Ruifang Su,Yunying Zhao*, Yu Deng*. Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in Saccharomyces cerevisiae. Metabolic Engineering. 2022 May 25;73:1-10. doi: 10.1016/j.ymben.2022.05.007. Online ahead of print. (IF=8.829)
2.Shiyun Li, Lizhou Ma, Wenxuan Fu, Ruifang Su,Yunying Zhao*, Yu Deng*. A programmable synthetic upstream activating sequence library for fine-tuning gene expression levels in Saccharomyces cerevisiae. ACS synthetic Biology. 2022, 18;11(3):1228-1239. (IF=5.249).
3.Li, Guohui, Wenxuan Fu, Yu Deng, andYunying Zhao*. Role of Calcium/Calcineurin Signalling in Regulating Intracellular Reactive Oxygen Species Homeostasis in Saccharomyces cerevisiae. Genes. 12(9):1311. (IF=4.141)
4.Yunying Zhao, Shiyun Li, Jing Wang, Yingli Liu, Yu Deng*. Roles of High Osmolarity Glycerol and Cell Wall Integrity Pathways in Cadmium Toxicity in Saccharomyces cerevisiae. International Journal of Molecular Sciences. 2021, 22(12):6169. (IF=6.208).
5.Yunying Zhao, Jie Li, Chunlei Cao*. Genome-wide analysis of manganese homeostasis in Saccharomyces cerevisiae. Journal of Microbiology and Biotechnology. 2021 Mar 26. doi: 10.4014/jmb.2012.12044. Online ahead of print. (IF=3.277)
6.Yunying Zhao, Jie Li, Ruifang Su, Yingli Liu, Jing Wang, Yu Deng*. Effect of magnesium ions on glucaric acid production in the engineered Saccharomyces cerevisiae. Journal of Biotechnology. 2021, 332:61-71. (IF=3.595)
7.Yunying Zhao, Chunlei Cao, Yingli Liu, Jing Wang, Shiyun Li, Jie Li, Yu Deng*. Genetic analysis of oxidative and endoplasmic reticulum stress responses induced by cobalt toxicity in budding yeast. Biochimica et Biophysica Acta-General Subjects. 2020, 1864(3):129516. (IF=4.117).
8.Li Shiyun , Qiyue Zhang, Jing Wang, Yingli Liu,Yunying Zhao*, Yu Deng*. Recent Progress in metabolic engineering of Saccharomyces cerevisiae for the production of malonyl-CoA derivatives. Journal of Biotechnology, 2020, 325: 83-90. (IF=3.595)
9.Yunying Zhao, Chunlei Cao, Yingli Liu, Jing Wang, Jie Li, Shiyun Li, Yu Deng*. Identification of the genetic requirements for zinc tolerance and toxicity in Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics. 2020, 10(2):479-488. (IF=3.542).
10.Cao Chunlei, Cao Zhifeng, Yu Peibin,Zhao Yunying*. Genome-wide identification for genes involved in sodium dodecyl sulfate toxicity in Saccharomyces cerevisiae. BMC Microbiology, 2020, 20: 34. https://doi.org/10.1186/s12866-020-1721-2. (IF=4.465).
11.Na Chen, Jingya Wang,Yunying Zhao*and Yu Deng*. Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer. Microbial Cell Factories, 2018, 17:67. (IF = 6.352)
12.Zhao Yunying, Xu Huihui, Zhang Yan, Jiang L* (2016) Vcx1-D1 (M383I), the Vcx1 mutant with a calcineurin-independent vacuolar Ca(2+)/H(+) exchanger activity, confers calcineurin-independent Mn(2+) tolerance in Saccharomyces cerevisiae. Can J Microbiol 62(6):475-484. (IF = 3.226)
13.Zhao Yunying, Yan Hongbo, Happeck R, Peiter-Volk T, Xu Huihui, Zhang Yan, Peiter E, van Oostende Triplet C, Whiteway M, Jiang Linghuo* (2016) The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast. Eur J Cell Biol 95(3-5):164-174. (IF = 6.020)
14.Zhao Yunying, Xiong Bing, Xu Huihui, Jiang Linghuo* (2014) Expression of NYV1 encoding the negative regulator of Pmc1 is repressed by two transcriptional repressors, Nrg1 and Mig1. FEBS Letters 588(17):3195-3201.(IF = 3.864)
15.Zhao Yunying, Du Jingcai, Xiong Bing, Xu Huihui, Jiang Linghuo* (2013) ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast. Journal of Molecular Cell Biology 5(5):336-344. (IF = 8.185)
16.Zhao Yunying, Du Jingcai, Zhao Gang, Jiang Linghuo* (2013) Activation of calcineurin is mainly responsible for the calcium sensitivity of gene deletion mutations in the genome of budding yeast. Genomics 101(1) 49-56. (IF = 4.310)
二、专利情况
1.邓禹，赵运英，李诗韵，李国辉，周胜虎，毛银一种酿酒酵母通过丙氨酸途径生产丙二酸的方法. 202111333071X
2.邓禹，赵运英，李诗韵，周胜虎，李国辉，毛银一种提高酿酒酵母生产丙二酸的方法.2021113333760
3.邓禹，赵运英，李杰，李国辉，毛银，周胜虎一种提高酿酒酵母工程菌株合成葡萄糖二酸效率的方法.2019114128234
4.邓禹，赵运英，李杰，毛银，周胜虎，李国辉一种提高酿酒酵母工程菌生产葡萄糖二酸的发酵方法.2019114128643
5.邓禹，赵运英，李诗韵，李国辉，毛银，周胜虎一种丙二酸的全生物合成的方法.2019114208510
6.邓禹，张熙，赵运英，李国辉，毛银，周胜虎一种利用酿酒酵母生产己二酸的方法.2019112128244
7.邓禹，赵梅，赵运英，毛银，周宇，隋雪，黄荻萱一种产己二酸的大肠杆菌重组菌及其应用. 201711138990.5
8.邓禹，邹宗胜，赵运英，毛银一株植物乳杆菌及其在发酵饲料方面的应用. 201710749942.3
9.曹春蕾，赵运英，曹正锋，余培斌，毛银，一种具有克霉唑抗性的酿酒酵母及其应用.201810680224.X
10.曹春蕾，赵运英，曹正锋，余培斌，毛银，一种具有酮康唑抗性的酿酒酵母及其应用.201810680236.2
三、承担教学科研项目情况
1. 2022合成生物学国家重点研发计划课题，参与；
2.江苏省自然科学基金面上项目(BK20181345)，主持；
3.工业生物技术教育部重点实验室开放课题(KLIB-KF201807)，主持；
4.国家自然科学基金项目(31301021)，主持；
5.中国博士后基金一等资助(2014M550263)，主持；
6.国家自然科学基金面上项目(81371784)，参与；
7.国家自然科学基金面上项目(81571966)，参与。
四、获奖情况（含指导学生获奖）
1.指导2篇学生论文获得2018年江南大学本科优秀毕业设计（论文）
2.指导大学生分别获得2020年生命科学竞赛二等奖和三等奖
以上资料更新时间截止：2022年9月
