承担科研项目：

1.“十四五”国家重点研发计划青年科学家项目，植物基人造肉中风险因子毒性可视化精准筛查与传感检测关键技术研究(2022YFF11003000)，主持

2.中国科协“2017-2019年度青年人才托举工程”，粮油制品质量安全控制技术研究(2017QNRC001)，主持

3.国家自然科学基金（面上项目），基于适配体荧光纳米探针的呕吐毒素细胞毒性成像分析研究(32072310)，主持

4.国家自然科学基金（面上项目），上转换-二氧化钛红外光催化降解呕吐毒素作用机理及产物安全性评价研究(31772086)，主持

5.国家自然科学基金（青年项目），基于增敏型上转换荧光纳米探针的微生物毒素检测新方法研究(31401576)，主持

6.国家科技支撑计划子课题，水产品加工过程中安全危害的现场识别与检测技术(2015BAD17B02)，主持

7.江苏省重点研发计划项目（现代农业），农产品品质与安全智能检测关键共性技术研发(BE2016306)，主持

8.江苏省农业科技自主创新资金项目，食用农产品安全典型危害物高效识别与控制技术创新与集成应用(CX(18)2025-01)，主持

9.岭南现代农业科学与技术广东省实验室，水产品中禁用药物的前处理及智能传感检测关键技术研究(NZ2021037)，主持

10.新疆兵团重点领域科技攻关计划，基于适配体的奶牛早孕低成本快速检测技术研发与推广应用(2023AB009-01)，参与

11.广州市科技计划项目，基于适配体识别传感的食品危害物检测平台及监控系统开发(202206010096)，参与

12.中国博士后科学基金第九批特别资助，基于适配体识别的多种食源性致病菌快速检测技术研究(2016T90430)，主持

13.中国博士后科学基金面上一等，基于适配体识别上转换荧光标记的检测试纸条设计研究(2015M580402)，主持

14.江苏省博士后科研资助计划，基于适配体识别的食源性致病菌可视化检测技术研究(1601087B)，主持

15.江苏省科技支撑计划子课题，农产品与食品中真菌毒素三联快速检测试纸的关键技术开发及产业化示范(BE2013732)，主持

16.江苏检验检疫局项目，基于ZnS:Mn量子点标记的沙门氏菌快速检测新方法研究(2018KJ35)，参与

17.江南大学自主科研计划，新型纳米材料在生物毒素标记检测及光催化降解中的应用研究(JUSRP11436)，主持

18.基于多维度响应的葡萄酒真伪及品质鉴定共性技术平台开发，横向课题

19.食品中危害物检测与功能因子挖掘评估，横向课题

20.婴幼儿食品中危害物的检测技术研究，横向课题

21.大米新鲜度快速测定，横向课题

22.食品检测中样品前处理净化富集技术开发，横向课题

23.生物可降解垃圾解决方案的研发与安全性控制，横向课题

24.叶酸可视化检测探针构筑及细胞成像，横向课题

25.荞麦酒中风味物质及功能性成分的测定研究

代表性学术论文：

1.Jiajun Wu, Xianfeng Lin, Jin Li, Ziyu Lv, Nuo Duan, Zhouping Wang,ShijiaWu^*. Dual-color nanospheres based on aggregation-induced emission and catalytic hairpin assembly for simultaneous imaging of acrylamide and miR-21 in living cells.Journal of Hazardous Materials, 2024, 462, 132815.

2.Xianfeng Lin, Changxin Li, Xiangyi Meng, Wenyan Yu, Nuo Duan, Zhouping Wang,Shijia Wu^*. CRISPR-Cas12a-mediated luminescence resonance energy transfer aptasensing platform for deoxynivalenol using gold nanoparticle-decorated Ti₃C₂T_XMXene as the enhanced quencher.Journal of Hazardous Materials, 2022, 433, 128750.

3.Chuxian He, You Zhou, Xianfeng Lin, Nuo Duan, Zhouping Wang,Shijia Wu^*. Deoxynivalenol-induced cell apoptosis monitoring using a cytochrome c-specific fluorescent probe based on a photoinduced electron transfer reaction.Journal of Hazardous Materials, 2021, 415, 125638.

4.Jin Li, Xianfeng Lin, Jiajun Wu, Dichen Ying, Nuo Duan, Zhouping Wang,Shijia Wu^*. Multifunctional magnetic composite nanomaterial for Colorimetric-SERS Dual-Mode detection and photothermal sterilization of Vibrio parahaemolyticus.Chemical Engineering Journal, 2023, 477, 147113.

5.Nuo Duan, Yuting Chang, Tingting Su, Xinyue Zhang, Minghui Lu, Zhouping Wang,Shijia Wu^*. Generation of a specific aptamer for accurate detection of sarafloxacin based on fluorescent/colorimetric/SERS triple-readout sensor.Biosensors & Bioelectronics, 2024, 249, 116022.

6.Jiajia Lv, Sen Zhao,Shijia Wu^*, Zhouping Wang^*. Upconversion nanoparticles grafted molybdenum disulfide nanosheets platform for microcystin-LR sensing.Biosensors & Bioelectronics, 2017, 90, 203-209.

7.Shaoliang Dai^#,Shijia Wu^#, Nuo Duan, Jian Chen, Zhigao Zheng, Zhouping Wang^*. An ultrasensitive aptasensor for Ochratoxin A using hexagonal core/shell upconversion nanoparticles as luminophores.Biosensors & Bioelectronics, 2017, 91, 538-544.

8.Shijia Wu, Nuo Duan, Changqing Zhu, Xiaoyuan Ma, Miao Wang, Zhouping Wang^*. Magnetic nanobead-based immunoassay for the simultaneous detection of aflatoxin B₁and ochratoxin A using upconversion nanoparticles as multicolor labels.Biosensors & Bioelectronics,2011, 30(1), 35-42.

9.Wenyan Yu, Lixin Kang, Xianfeng Lin, Nuo Duan, Dichen Ying, Zhouping Wang, andShijia Wu^*. Deoxynivalenol (DON)-Triggered Dual-Color Composite Probe Based on Gold Nanoclusters for Simultaneous Imaging of DON and miR-34a in Living Cells.Analytical Chemistry, 2023, 95, 50, 18611-18618.

10.Shijia Wu, Nuo Duan, Shi Zhao, Congcong Fang, Zhouping Wang^*. Simultaneous Aptasensor for Multiplex Pathogenic Bacteria Detection Based on Multicolor Upconversion Nanoparticles Labels.Analytical Chemistry, 2014, 86(6), 3100-3107.

11.Shijia Wu, Nuo Duan, Xiaoyuan Ma, Yu Xia, Hongxin Wang, Zhouping Wang^*, and Qian Zhang^*. Multiplexed Fluorescence Resonance Energy Transfer Aptasensor between Upconversion Nanoparticles and Graphene Oxide for the Simultaneous Determination of Mycotoxins.Analytical Chemistry, 2012, 84(14), 6263-6270.

12.Xinyu Tong, Xianfeng Lin, Nuo Duan, Zhouping Wang,Shijia Wu^*. Laser-Printed Paper-Based Microfluidic Chip Based on a Multicolor Fluorescence Carbon Dot Biosensor for Visual Determination of Multiantibiotics in Aquatic Products.ACS Sensors, 2022, 7, 3947−3955.

13.Xianfeng Lin, Jin Li, Jiajun Wu, Kaixi Guo, Nuo Duan, Zhouping Wang,Shijia Wu^*. Fe-Co-Based Metal-Organic Frameworks as Peroxidase Mimics for Sensitive Colorimetric Detection and Efficient Degradation of Aflatoxin B₁.ACS Applied Materials & Interfaces, 2024, 10.1021/acsami.3c18878.

14.Xuhan Xia, Ting Zhang, Sha Deng, Junbo Chen,Shijia Wu^*, Chuxian He, Kaxixiang Zhang, Ruijie Deng*, Qiang He. Visualization of Mycotoxins in Living Cells Using Conformation-Resolved Aptamer Nanoprobes.ACS Sustainable Chemistry & Engineering, 2020, 8, 9920-9925.

15.Xinyu Tong, Xianfeng Lin, Nuo Duan, Ziyu Lv, Zhouping Wang,Shijia Wu^*. A novel colorimetric and fluorescent dual-mode 3D paper-based microfluidic aptasensor for the point-of-care detection of sulfadimethoxine.Sensors and Actuators: B. Chemical, 2023, 397, 134691.

16.Nuo Duan, Xiaowan Chen, Xianfeng Lin, Dichen Ying, Zhouping Wang, Wenbo Yuan^*,Shijia Wu^*. Paper-based fluorometric sensing of malachite green using synergistic recognition of aptamer-molecularly imprinted polymers and luminescent metal–organic frameworks,Sensors & Actuators: B. Chemical, 2023, 384 133665.

17.You Zhou, Nuo Duan, Yan Lv, Imran Mahmood Khan, Shuo Qi, Xianfeng Lin, Wenyan Yu, Yin Zhang, Wei Xu, Jianhong Xu,Shijia Wu^*, Zhouping Wang^*. Fluorescence imaging of glutathione with aptasensor and monitoring deoxynivalenol-induced oxidative stress in living cells.Sensors and Actuators: B. Chemical, 2022, 354, 131190.

18.Nuo Duan, Changxin Li, Xiaoyin Zhu, Shuo Qi, Zhouping Wang,Shijia Wu^*. Stimultaneous coupled with Separate SELEX for heterocyclic biogenic amine-specific aptamers screening and their application in establishment of an effective aptasensor.Sensors and Actuators: B. Chemical, 2022, 352, 130985.

19.Shijia Wu, Nuo Duan, Xiaoyuan Ma, Yu Xia, Ye Yu, Zhouping Wang^*, Hongxin Wang. Simultaneous detection of enterovirus 71 and coxsackievirus A16 using dual-colour upconversion luminescent nanoparticles as lables.Chemical Communications, 2012, 48(40), 4866-4868.

20.Nuo Duan, Kexin Ren, Chen Lyu, Zhouping Wang,Shijia Wu^*. Discovery and Optimization of an Aptamer and Its Sensing Ability to Amantadine Based on SERS via Binary Metal Nanoparticles.Journal of Agricultural and Food Chemistry, 2022, 70(46), 14805-14815.

21.Nuo Duan, Mingqian Song, Weiyu Mi, Zhouping Wang,Shijia Wu^*. Effectively Selecting Aptamers for Targeting Aromatic Biogenic Amines and Their Application in Aptasensing Establishment.Journal of Agricultural and Food Chemistry, 2021, 69(48), 14671-14679.

22.Liling Hao, Wei Wang, Xueqing Shen, Shuliu Wang, Qian Li, Faliang An, andShijia Wu^*. A Fluorescent DNA Hydrogel Aptasensor Based on the Self-Assembly of Rolling Circle Amplification Products for Sensitive Detection of Ochratoxin A.Journal of Agricultural and Food Chemistry, 2020, 68(1), 369-375.

23.Shijia Wu, Lihong Liu, Nuo Duan, Qian Li, You Zhou, and Zhouping Wang^*. Aptamer-Based Lateral Flow Test Strip for Rapid Detection of Zearalenone in Corn Samples.Journal of Agricultural and Food Chemistry, 2018, 66(8), 1949-1954.

24.Lehan Zhao, Xianfeng Lin, Nuo Duan, Imran Mahmood Khan, Zhouping Wang,Shijia Wu^*. A sensitive fluorescent assay based on gold-nanoclusters coated on molecularly imprinted covalent organic frameworks and its application in malachite green detection,Food Chemistry, 2023, 410, 135425.

25.Xianfeng Lin, Changxin Li, Xinyu Tong, Nuo Duan, Zhouping Wang,Shijia Wu^*. A portable paper-based aptasensor for simultaneous visual detection of two mycotoxins in corn flour using dual-color upconversion nanoparticles and Cu-TCPP nanosheets.Food Chemistry, 2023, 404, 134750.

26.Nuo Duan, Qian Li, Xiangyi Meng, Zhouping Wang,Shijia Wu^*. Preparation and characterization of k-carrageenan/konjac glucomannan/TiO₂nanocomposite film with efficient anti-fungal activity and its application in strawberry preservation.Food Chemistry, 2021, 364, 130441.

27.Xianfeng Lin, Qianru Yu, Wei Yang, Chuxian He, You Zhou, Nuo Duan,Shijia Wu^*. Double-enzemes-mediated fluorescent assay for sensitive determination of organophosphorus pesticides based on the quenching of upconversion nanoparticles by Fe³⁺.Food Chemistry, 2021, 345, 128809.

28.Shijia Wu, Fang Wang, Qian Li, Jing Wang, You Zhou, Nuo Duan, Sobia Niazi, Zhouping Wang^*. Photocatalysis and degradation products identification of deoxynivalenol in wheat using upconversion nanoparticles@TiO₂composite.Food Chemistry, 2020, 323, 126823.

29.You Zhou,Shijia Wu^*, Fang Wang, Qian Li, Chuxian He, Nuo Duan, Zhouping Wang*. Assessing the toxicity in vitro of degradation products from deoxynivalenol photocatalytic degradation by using upconversion nanoparticles@TiO₂composite.Chemosphere, 2020, 238, 124648.

30.Shijia Wu, Nuo Duan, Zhao Shi, Congcong Fang, Zhouping Wang^*. Dual fluorescence resonance energy transfer assay between tunable upconversion nanoparticles and controlled gold nanoparticles for the simultaneous detection of Pb²⁺and Hg²⁺.Talanta,2014, 128, 327-336.

获奖：

1. 中国粮油学会第三届青年科技奖，2022，排名第一

2.“食品安全危害物适配体SELEX筛选体系及纳米生物界面组装研究”，高等学校新利18体育官网登录网址优秀成果奖-自然科学奖二等奖，2017，排名第二

3.“食品安全纳米生物检测技术研究及产业化示范”，中国轻工业联合会科技进步奖二等奖，2014，排名第二

4.“食源性致病菌/真菌毒素纳米生物传感检测技术研究及应用”，中国食品科学技术学会科技进步奖三等奖，2014，排名第二

5.“食品中真菌毒素检测新技术研究”，中山市科学技术进步奖二等奖，2014，排名第四

已授权发明专利：

1.一种可视化监测活细胞中细胞色素C和评估呕吐毒素细胞毒性的方法，授权，2021年12月28日，发明人：吴世嘉，何楚娴，周游，林先锋，专利号：ZL202110149119.5

2.一种用于赭曲霉毒素A快速检测的上转换适配体试纸条的制备方法，授权，2021年5月11日，发明人：吴世嘉，刘丽红，段诺，王周平，虞倩茹，专利号：201810502981.8

3.一种复合纳米材料光催化降解脱氧雪腐镰刀菌烯醇的方法，授权，2020年8月18日，发明人：吴世嘉，王芳，王周平，段诺，李倩，周游，专利号：201810377179.0

4.一种适配体过氧化物模拟酶可视化检测沙门氏菌的方法，授权，2019年7月30日，发明人：吴世嘉，段诺，王周平，刘丽红，专利号：ZL201710253103.2

5.一种基于上转换发光纳米材料和金纳米棒之间发光共振能量转移检测赭曲霉毒素A的方法，授权，2018年9月11日，发明人：吴世嘉，戴邵亮，王周平，段诺，专利号：ZL201510633405.3

6.一种基于荧光共振能量转移检测伏马菌毒素B1的方法，授权，2016年9月28日，发明人：王周平，吴世嘉，段诺，马小媛，夏雨，专利号：ZL201210570159.8

7.一种基于多色上转换荧光标记同时检测三种食源性致病菌的方法，授权，2016年6月22日，发明人：王周平，吴世嘉，段诺，史召，方聪聪，专利号：ZL201410057135.1

8.试纸条荧光生物检测系统，授权，2016年4月13日，发明人：王周平，吴世嘉，戴邵亮，段诺，李琪，夏雨，马小媛，专利号：ZL201520946179.X

9.超高压液相色谱—飞行时间质谱同时测定白酒中六种微量甜味剂的方法，授权，2012年6月27日，发明人：王洪新，吴世嘉，陶冠军，专利号：ZL200910184787.0

10.一种适配体功能化磁性纳米材料磁分离—上转换荧光纳米材料标记检测赭曲霉毒素A的方法，授权，2012年2月22日，发明人：王周平，吴世嘉，段诺，专利号：ZL201010295782.8

承担教学：

《食品安全学》 本科生

《食品分析（实验）》 本科生

《微生物与食品安全》 研究生