1）陈坚,周景文,郭洪伟,堵国成.Genetically engineered Yarrowia Lipolytica with enhanced extracellular secretion of α-ketoglutarate , US9328363.

2）陈坚,康振,堵国成,金鹏.A method of constructing a recombinant Bacillus subtilis that can produce hyaluronic acids within certain molecular weight ranges, US9771607.

3）陈坚,堵国成,康振,金鹏.Novel leech hyaluronidase and its application，US9279111.

4）陈坚,周景文,郭洪伟,吕永坤,堵国成.A method for decreasing pyruvate catabolism and increasing the accumulation of pyruvate in microbes, US9279111.

5）Chen Jian, Du Guocheng, Li Jianghua, Liu Long, Feng Zhuolin, Method for increasing catalase production.授权专利号：US 8/722, 364.

6）Chen Jian, Du Guocheng, Liu Long, Li Jianghua, Guan Ningzi.Method for improving acid tolerance of Propionibacterium acidipropionici.授权专利号：US 9/187, 773.

7）Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Gu Yang, Song Yang, Deng Jieying, ZhaoYawen. Method for improving GlcNAc production of recombinant Bacillus subtilis.授权专利号：US 9/868, 970.

8）Chen Jian, Du Guocheng, Liu Long, Li Jianghua, Yin Xian. Promoter and use thereof.授权专利号：US 15/349,025.

9）Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Liu Yanfeng, Link Hannes, Sauer Uwe. Method for enhancing N-acetylglucosamine Production through glcK Knockout of Bacillus subtilis.授权专利号：US 14/934,166.

10）Jian Chen, Jingwen Zhou, Hongwei Guo, Guocheng Du. A genetically engineered Yarrowia lipolytica with enhanced extracellular secretion of a-ketoglutarate，US 14/142,897；

11）Jian Chen, Jingwen Zhou, Hongwei Guo, Guocheng Du. A genetically engineered Torulopsis glabrata with enhanced extracellular secretion of pyruvic acid，US 9,447,437；

12）Jian Chen, Jingwen Zhou, Hongwei Guo, Yongkun Lv, Guocheng Du. Method for decreasing pyruvate catabolism and increasing of the accumulation of pyruvate in microbes. US 9,518,275.

Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Niu Tengfei. Recombinant Bacillus subtilis for producing acetylglucosamine and construction method thereof.授权专利号：US 10, 093, 936.

13）Liu Long, Chen Jian, Du Guocheng, Yin Xian, Li Jianghua. Promoter and use thereof.授权专利号：US 9,926,569.

14）Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Liu Yanfeng, Hannes Link, Uwe Sauer. Method for enhancing Nacetylglucosamine production through glck knockout of Bacillus subtilis.授权专利号：US 9,914,949.

15）Liu Long, Chen Jian, Du Guocheng, Yin Xian, Li Jianghua. Method of gene expression regulation.授权专利号：US2018/0171344.

16）Liu Long, Chen Jian, Du Guocheng, Li Jianghua, Gu Yang, Song Yang, Deng Jieying, Zhao Yawen. Method for improving GlcNAc production of recombinant Bacillus subtilis.授权专利号：US 9,868,970.

17）Chen Jian, Du Guocheng, Liu Long, Li Jianghua, Guan Ningzi. Method for improving acid tolerance of Propionibacterium acidipropionici.授权专利号：US 9,187,773.

18）Chen Jian, Du Guocheng, Li Jianghua, Liu Long, Feng Zhuolin. Method for increasing microbial catalase production.授权专利号：US 8,722,364.

19）Liu Long, Li Jianghua, Niu Tengfei, Chen Jian, Du Guocheng. Recombinant Bacillus subtilis for increasing production of acetylglucosamine and construction method thereof.授权专利号：US 10, 465, 198.

20）Juan Zhang, Jian Chen, Zheng Peng, Guocheng Du. A Bacillus subtilis strain capable of expressing keratinase efficiently, PCT/CN2018/089937.

21）Juan Zhang, Zhengming Zhu, Jian Chen, Guocheng Du. A Lactococcus lactis and its application, PCT/CN2016/108476.

22）Jian Chen, Guochceng Du, Xinyao Lu, Song Liu, Juan Zhang. Method for improving thermal stability of enzymes, US 9,040,274 B2.

23）周景文,陈坚,宁萌,堵国成,曾伟主,曹晓梅,张秋菊,方俊. 一种基于多机械臂系统的高通量筛选系统.US15708955.

24）刘延峰,堵国成,田荣臻,陈坚. 一种调控枯草芽孢杆菌中目的蛋白表达的方法.US16255054.

25）康振,陈坚,堵国成,周正雄. 一种酶法制备硫酸软骨素的方法.US15808944.

26）方芳,杨涛,周景文,陈坚,堵国城,徐洁. 一种耐盐性提高的多铜氧化酶突变体.US16524382.

27）刘龙,陈坚,堵国成,吕雪芹,李江华,姜竹,卢伟,张弘治,卢健行,刘长峰. 一种高效分泌表达几丁二糖脱乙酰酶的工程菌构建及其应用.US16503699.

28）Fang Zhong, Fei Liu, Hongxiang Liu, Maoshen Chen, Feifei Xu. Method for preparing double-layered bursting beads with milk tea flavor. US16842815.

29）Liu Long, Lv Xueqin, Du Guocheng, Li Jianghua, Chen Jian. Recombinant Bacillus subtills and use thereof. US 11,136,545.

30）Liu Long, Gu Yang, Deng Jieying, Chen Jian, Du Guocheng, Li Jianghua. Method for promoting acetylglucosamine synthesis of Bacillus subtilis. US 11,198,862.

31）Liu Long, Chen Jian, Lv Xueqin, Du Guocheng, Li Jianghua, Deng Jieying, Liu Ke. Recombinant Bacillus subtills with improved 2’-fucosyllactose production, and construction method thereof. US 11,293,027.

32）Lu Jianxing, Liu Long, Chen Jian, Liu Changfeng, Lv Xueqin, Du Guocheng, Li Jianghua, Deng Chen, Lu Jiangong. Transcription factor sugr conding gene, and use thereof in production of N-acetylglucosamine. US 11,512,319.

33）Juan Zhang, Jian Chen, Zheng Peng, Guocheng Du. Recombinant Bacillus Subtilis Engineered Bacterium Capable of efficiently Expressing Keratinase. US 17/104,122.

34）周景文,陈坚,刘立,曾伟主,堵国成.一种提高山梨糖产量和生产强度的方法. US 11,242,548.