代表性学术论文

方向一：

1.Yicheng Wang, Yusuke Maeda, Yi-Shi Liu, Yoko Takada, Akinori Ninomiya, Tetsuya Hirata, Morihisa Fujita, Yoshiko Murakami, and Taroh Kinoshita.Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation.Nature Communications. 2020, 11(1): 860.

2.Rongfeng Cai, Zhongwen Zhang, Haohan Chen, Yaping Tian, Nandi Zhou. A versatile signal-on electrochemical biosensor forStaphylococcus aureusbased on triple-helix molecular switch.Sensors and Actuators B: Chemical.2020, 326: 128842.

3.Rongfeng Cai, Fan Yin, Haohan Chen, Yaping Tian, Nandi Zhou. A fluorescent aptasensor forStaphylococcus aureusbased on strand displacement amplification and self-assembled DNA hexagonal structure.Microchimica Acta. 2020, 187: 304.

4.Hao Wei, Rongfeng Cai, Hui Yue, Yaping Tian, Nandi Zhou. Screening and application of a truncated aptamer for high-sensitive fluorescent detection of metronidazole.Analytica Chimica Acta.2020, 1128: 203-210.

5.Xiaoman Zhou, Ganglong Yang, Feng Guan. Biological Functions and Analytical Strategies of Sialic Acids in Tumor.Cells. 2020, 9(2): 273.

6.Yi-Shi Liu, Morihisa Fujita. Mammalian GPI-anchor modifications and the enzymes involved.Biochemical Society Transactions. 2020, 48(3): 1129-1138.

7.Mostafa Basiony, Yan Yang, Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Studies on the Properties of the Sporulation Specific Protein Dit1 and its Product Formyl Tyrosine.Journal of Fungi. 2020, 6(2): 77.

8.Xin-Yu Guo, Yi-Shi Liu, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita. Calnexin mediates the maturation of GPI-anchors through ER retention.Journal of Biological Chemistry. 2020, doi:10.1074/jbc.RA120.015577.

9.Gun-Hee Lee, Morihisa Fujita, Hideki Nakanishi, Haruhiko Miyata, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, and Taroh Kinoshita.PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins.Journal of Biological Chemistry. 2020, 295(42): 14501-14509.

10.Zijie Li, Fen Li, Li Cai, Zhou Chen, Ling Qin, Xiao-Dong Gao. One-pot multienzyme synthesis of rare ketoses from glycerol.Journal of Agricultural and Food Chemistry. 2020, 68(5): 1347.

11.Zijie Li, Xiaoxiao Liu, Hideki Nakanishi, Xiao-Dong Gao. Encapsulation of mannose-6-phosphate isomerase in yeast spores and its application in L-ribose production.Journal of Agricultural and Food Chemistry. 2020, 68(25): 6892.

12.Wenyan Chen, Rong Wang, Dan Li, Chenyang Zuo, Piaopiao Wen, Haili Liu, Yongquan Chen, Morihisa Fujita, Zhimeng Wu, Ganglong Yang. Comprehensive analysis of the glycome and glycoproteome of bovine milk-derived exosomes.Journal of Agricultural and Food Chemistry. 2020, doi:10.1021/acs.jafc.0c04605J.

13.Qiang Chao, Yi Ding, Zheng-Hui Chen, Meng-Hai Xiang, Ning Wang, Xiao-Dong Gao. Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans.Frontiers in Chemistry. 2020, 8: 513.

14.Ying Ou, Xin Jin, Jingwen Fang, Yaping Tian, Nandi Zhou. Multi-cycle signal-amplified colorimetric detection of tobramycin based on dual-strand displacement and three-way DNA junction.Microchemical Journal.2020, 156: 104823.

15.Zhou Chen, Zijie Li, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao. Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase.Enzyme and Microbial Technology. 2020, 133: 109456.

16.Kankai Shao, Feng Li, Yan Yang, Ning Wang, Xiao-Dong Gao, Hideki Nakanishi. Characteristics of SNARE proteins are defined by distinctive properties of SNARE motifs.Biochem Biophys Acta Gen Subjects. 2020, 186: 129658.

17.Yifan Jin, Michiyo Okamoto, Hiroji Chibana, Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Functional characteristics of Svl3 and Pam1 that are required for proper cell wall formation in yeast cells.Yeast. 2020, 37: 359-371.

18.Zhou Chen, Zijie Li, Fen Li, Ning Wang, Xiao-Dong Gao. Characterization of alditol oxidase fromStreptomyces coelicolorand its application in the production of rare sugars.Bioorganic＆Medicinal Chemistry. 2020, 28 (10): 115464.

19.Yi-Shi Liu, Matabaro Emmanuel, Xiao-Dong Gao, Morihisa Fujita. Selecting cells expressing high levels of recombinant proteins using the GPI-anchored protein with selenocysteine system.Journal of Bioscience and Bioengineering. 2020,doi:10.1016/j.jbiosc.2020.10.004.

20.Cheng Jing, Haohan Chen, Rongfeng Cai, Yaping Tian, Nandi Zhou. An electrochemical aptasensor for ATP based on a configuration-switchable tetrahedral DNA nanostructure.Analytical Methods.2020, 12: 3285-3289.

21.Ji-Xiang Jia, NdayambajeYvan Kalisa, Tian-Tian Lu, Zhifang Zhou, Xiao-Dong Gao, Ning Wang. Chemo-enzymatic synthesis of the ALG1-CDG biomarker and evaluation of its immunogenicity.Bioorganic＆Medicinal Chemistry Letters. 2020, 30: 127614.

22.Shen-Bao Zhao, Neta Dean, Xiao-Dong Gao, Morihisa Fujita.MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes.Cell Structure and Function. 2020, 45(1): 77-92.

23.Dehua Liu, Dawei Zhang, Qinqin Huang, Lili Gu, Nandi Zhou, Yaping Tian. Mutagenesis for improvement of activity and stability of prolyl aminopeptidase fromAspergillus oryzae.Applied Biochemistry and Biotechnology.2020, 191: 1483-1498.

24.Ran Cao, Tian-Chan Zhang, Ya-Ran Chen, Cui Cao, Huan Chen, Yi-Fan Huang, Morihisa Fujita,Li Liu, Josef Voglmeir.Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants.Glycoconjugate Journal. 2020, doi: 10.1007/s10719-020-09946-8.

25.Feng Li, Ganglong Yang, Tachikawa H., Kankai Shao, Yan Yang, Xiao-Dong Gao, Hideki Nakanishi. Identification of novel O-GlcNAc transferase substrates using yeast cells expressing OGT.Journal of Generaland Applied Microbiology. 2020, In press.

26.Guoyu Liu, Xiao-Dong Gao, Hideki Nakanishi. Unique properties of theS. cerevisiaespore wall and its applications.Trends in Glycoscience Glycotechnology. 2020, In press.

27.金则成,喜多岛敏彦,藤田盛久,高晓冬.哺乳动物细胞中糖链结构的改造.《食品与生物技术学报》. 2020, 2: 39-46.

方向二：

28.Jun Hu, Wenrui Wu, Yufei Qin, Chao Liu, Peng Wei, Jing Hu, Peter H. Seeberger, Jian Yin. Fabrication of glyco-metal-organic frameworks for targeted interventional photodynamic/chemotherapy for hepatocellular carcinoma through percutaneous transperitoneal puncture.Advanced Functional Materials. 2020, 30(19): 1910084.

29.Juntao Cai, Jing Hu, Chunjun Qin, Lingxin Li, Dacheng Shen, Guangzong Tian, Xiaopeng Zou, Peter H. Seeberger, Jian Yin. Chemical synthesis elucidates the key antigenic epitope of the autism-related bacteriumClostridium bolteaecapsular octadecasaccharide.Angewandte Chemie International Edition. 2020, doi:10.1002/anie.202007209.

30.Guangzong Tian, Jing Hu, Chunjun Qin, Lingxin Li, Xiaopeng Zou, Juntao Cai, Peter H. Seeberger, Jian Yin. Chemical synthesis and immunological evaluation of Helicobacter pylori serotype O6 tridecasaccharide O-antigen containing a unique DD-heptoglycan.Angewandte Chemie International Edition. 2020, 59(32): 13362-13370.

31.Juan Zhou, Yuning Han, Yang Yang, Li Zhang, Hong Wang, Yiting Shen, Jiahui Lai, and Jinghua Chen. Phospholipid-Decorated Glycogen Nanoparticles for Stimuli-Responsive Drug Release and Synergetic Chemophotothermal Therapy of Hepatocellular Carcinoma.ACS Applied Materials & Interfaces. 2020, 12: 23311.

32.Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou, Jinghua Chen. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nanoparticles for Liver Cancer Therapy.Applied Materials Today. 2020, 18: 100521.

33.Shijie Dai, Shaozhong Liu, Chen Li, Zhifang Zhou, Zhimeng Wu. Site-selective modification of exendin 4 with variable molecular weight dextrans by oxime-ligation chemistry for improving type 2 diabetic treatment.Carbohydrate Polymers. 2020, 249, 116864.

34.Xinyu Chen, Junjie Fu, Feng Zhou, Qimeng Yang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Xuelin Tang, Neng Jiang, Jian Yin, Jing Han. Stapled and Xenopus Glucagon-Like Peptide 1 (GLP-1)-Based Dual GLP-1/Gastrin Receptor Agonists with Improved Metabolic Benefits in Rodent Models of Obesity and Diabetes.Journal of Medicinal Chemistry. 2020, doi:10.1021/acs.jmedchem.0c00736.

35.Han Lin, Haofei Hong, Jinfeng Wang, Chen Li, Zhifang Zhou, Zhimeng Wu. Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen.Chemical Communications. 2020, doi:10.1039/d0cc05263a.

36.Guangzong Tian, Chunjun Qin, Zhonghua Liu, Dacheng Shen, Xiaopeng Zou, Junjie Fu, Jing Hu, Peter H. Seeberger, Jian Yin. Total synthesis of the Helicobacter pylori serotype O2 O-antigenα-(1→2)- andα-(1→3)-linked oligoglucosides.Chemical Communications. 2020, 56(3): 344-347.

37.Jing Han, Junjie Fu, Qimeng Yang, Feng Zhou, Xinyu Chen, Chenglin Li, Jian Yin. Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents.European Journal of Medicinal Chemistry. 2020, 198, 112389.

38.Zhou Ye, Dong Hua, Yijian Rao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.Colloids and Surfaces A-Physicochemical and Engineering Aspects. 2020, 585, 124136.

39.Ming Zhao, Chunjun Qin, Lingxin Li, Haotian Xie, Beining Ma, Ziru Zhou, Jian Yin, Jing Hu. Conjugation of synthetic trisaccharide ofStaphylococcus aureustype 8 capsular polysaccharide elicits antibodies recognizing intact bacterium.Frontiers in Chemistry. 2020, 8, 258.

40.Yishu Yan, Xiaoni Liu, Yichao Zhuang, Yanduo Zhai, Xiting Yang, Yang Yang, Shicong Wang, Fei Hong, Jinghua Chen. Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice.Journal of Ethnopharmacology. 2020, 261, 113203.

41.Haiquan Yang, Yingfang Ma, Yuan Zhao, Wei Shen, Xianzhong Chen. Systematic engineering of transport and transcription to boost alkaline α-amylase production inBacillus subtilis.Applied Microbiology and Biotechnology.2020, 104: 2973-2985.

42.Yang Yang, Yanyan Zhang, Yishu Yan, Qian Ji, Yutong Dai, Suyuan Jin, Yanxian Liu, Jinghua Chen, Liping Teng. A Sponge-Like Double-Layer Wound Dressing with Chitosan and Decellularized Bovine Amniotic Membrane for Promoting Diabetic Wound Healing.Polymers. 2020, 12(3): 535.

43.Peng Wei, Zhou Ye, Shuya Cao, Shuo Bai, Peter H. Seeberger, Jian Yin, Jing Hu. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, 598, 124804.

44.Yang Chen, Li Duan, Yuqi Ma, Qingquan Han, Xin Li, Jieling Li, Anhe Wang, Shuo Bai, Jian Yin. Preparation of transient electronic devices with silk fibroin film as a flexible substrate.Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, 600, 124896.

45.Yan Zhang, Jiangli Lou, Min Li, Zhenbo Yuan, Yijian Rao. Emodin as a novel organic photocatalyst for selective oxidation of sulfides under mild conditions.The Royal Society of Chemistry Advances.2020, 10, 19747-19750.

46.Dan Li, Surui Yao, Zhifang Zhou, Jie Shi, Zhaohui Huang, Zhimeng Wu. Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin.Carbohydrate Research. 2020, 493, 108032.

47.Yunzhan Ning, Chunjun Qin, Wenbin Sun, Junjie Fu, Jing Hu, Jian Yin. Anomeric configuration-dependence of the Lattrell-Dax epimerization from D-glucose to synthetically useful D-allose derivatives.Chinese Journal of Natural Medicines. 2020, 18(10): 723-728.

48.Xiaopeng Zou, Chunjun Qin, Jing Hu, Junjie Fu, Guangzong Tian, Oren Moscovitz, Peter H.Seeberger, Jian Yin. Total synthesis of D-glycero-D-mannno-heptose 1β,7-bisphosphate with 3-O-amyl amine linker and its monophosphate derivative.Chinese Journal of Natural Medicines. 2020, 18(8): 628-632.

49.Jing Hu, Yong Xiao, Shu’an Shao, Rui Gu, Qimin Shi, Zhonghua Liu, Jian Yin. Construction and application of carbohydrate microarrays to detect foodborne bacteria.Chinese Journal of Natural Medicines. 2020, 18(3): 214-220.

50.Philippe Icyishaka, Chenxing Li, Liushen Lu, Wenhao Bao, Jia Li, Yan Zhang, Yijian Rao. Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions.Journal of Visualized Experiments.2020, e60786, Page1-18.

51.Lipeng Feng, Jie Shi, Haofei Hong, Zhifang Zhou, Zhimeng Wu. GM3 trisaccharide biosynthesis and process optimization using engineeredE. colilysate and whole-cell catalysis.Journal of Carbohydrate Chemistry.2020, 39, 217-231.

52.Chunjun Qin, Zhonghua Liu, Meiru Ding, Juntao Cai, Junjie Fu, Jing Hu, Peter H. Seeberger, Jian Yin. Chemical synthesis of thePseudomonas aeruginosaO11 O-antigen trisaccharide based on neighboring electron-donating effect.Journal of Carbohydrate Chemistry. 2020, 39(08): 374-397.

方向三：

53.Xianhao Xu, Xueliang Li, Yanfeng Liu, Yonglian Zhu, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Pyruvate-responsive genetic circuits for dynamic control of central metabolism.Nature Chemical Biology. 2020, 16, 1261-1268.

54.Rongzhen Tian, Yanfeng Liu, Yanting Cao，Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Titrating bacterial growth and chemical iosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction.Nature Communications. 2020, 11: 5078.

55.Yang Wang, Litao Hu, Hao Huang, Hao Wang, Tianmeng Zhang, Jian Chen, Guocheng Du, Zhen Kang. Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineeredCorynebacterium glutamicum.Nature Communications.2020, 11(1): 3120.

56.Xianhao Xu, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Microbial Chassis Development for Natural Product Biosynthesis.Trends in Biotechnology. 2020, 38(7): 779-796.

57.Xuerong Jin, Qing Li, Yang Wang, Weijiao Zhang, Ruirui Xu, Jianghua Li, Guocheng Du, Zhen Kang. Optimizing the sulfation-modification system for scale preparation of chondroitin sulfate A.Carbohydrate Polymers. 2020, 246: 116570.

58.Xueqin Lv, Yaokang Wu, Rongzhen Tian, Yang Gu, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. Synthetic metabolic channel by functional membrane microdomains for compartmentalized flux control.Metabolic Engineering.2020, 59: 106-118.

59.Xueqin Lv, Cheng Zhang, Shixiu Cui, Xianhao Xu, Lingling Wang, Jianghua Li, Guocheng Du, Jian Chen, Rodrigo Ledesma-Amaro, Long Liu. Assembly of pathway enzymes by engineering functional membrane microdomain components for improved N-acetylglucosamine synthesis inBacillus subtilis.Metabolic Engineering. 2020, 61: ‏ 96-105.

60.Shixiu Cui, Hongzhi Xia, Taichi Chen, Yang Gu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Cell Membrane and Electron Transfer Engineering for Improved Synthesis of Menaquinone-7 inBacillus subtilis.iScience. 2020, 23(3): 100918.

61.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Applications of CRISPR in a Microbial Cell Factory: From Genome Reconstruction to Metabolic Network Reprogramming.ACS Synthetic Biology. 2020, 9(9): 2228-2238.

62.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Applications of CRISPR in microbial cell factory: From genome re-construction to metabolic network re-programming.ACS Synthetic Biology. 2020, 9(9): ‏2228-2238.

63.Yunfeng Zhang, Qixing Liang, Chuanzhi Zhang, Juan Zhang, Guocheng Du, Zhen Kang. Improving production ofStreptomyces griseustrypsin for enzymatic processing of insulin precursor.Microbial Cell Factories.2020, 19 (1): 88.

64.Xiaomin Dong, Nan Li, Zhenmin Liu, Xueqin Lv, Yu Shen, Jianghua Li, Guocheng Du, Miao Wang, Long Liu. CRISPRi-Guided Multiplexed Fine-Tuning of Metabolic Flux for Enhanced Lacto-N-neotetraose Production inBacillus subtilis.Journal of Agricultural and Food Chemistry. 2020, 68(8): 2477-2484.

65.Han Yang, Yanfeng Liu, Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Systems metabolic engineering ofBacillus subtilisfor efficient biosynthesis of 5-methyltetrahydrofolate.Biotechnology and Bioengineering. 2020, 117: 2116-2130.

66.Yaokang Wu, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. CAMERS-B: CRISPR/Cpf1 assisted multiple-genes editing and regulation system forBacillus subtilis.Biotechnologyand Bioengineering. 2020, 117(6): 1817-1825.

67.Xueqin Lv, Ke Jin, Yaokang Wu, Cheng Zhang, Shixiu Cui, Xiaonan Zhu, Jianghua Li, Guocheng Du, Long Liu. Enzyme assembly guided by SPFH-induced functional inclusion bodies for enhanced cascade biocatalysis.Biotechnology and Bioengineering.2020, 117(5): 1446-1457. 4.002

68.Tengfei Niu, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu. The elucidation of phosphosugar stress response inBacillus subtilisguides strain engineering for high N-acetylglucosamine production.Biotechnology and Bioengineering. 2020; 1-14.

69.Hao Huang, Qixing Liang, Yang Wang, Jian Chen, Zhen Kang. High-level constitutive expression of leech hyaluronidase with combined strategies in recombinantPichia pastoris.Applied Microbiology and Biotechnology. 2020, 104(4): 1621-1632.

70.Panhong Yuan, Shixiu Cui, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Metabolic engineering for the production of fat-soluble vitamins: advances and perspectives.Applied Microbiology and Biotechnology.2020, 104(3): 935-951.

71.Yanfeng Liu, Anqi Su, Jianghua Li, Rodrigo Ledesma-Amaro, Peng Xu, Guocheng Du, Long Liu. Towards next-generation model microorganism chassis for biomanufacturing.Applied Microbiology and Biotechnology.2020, 104: 9095-9108.

72.Li Sun, Mengyue Gong, Xueqin Lv, Ziyang Huang, Yang Gu, Jianghua Li, Guocheng Du, Long Liu. Current advance in biological production of short-chain organic acid.Applied Microbiology and Biotechnology. 2020, 104: 9109-9124.

73.Panhong Yuan, Shixiu Cui, Yanfeng Liu, Jianghua Li, Xueqin Lv, Long Liu, Guocheng Du. Combinatorial engineering for improved menaquinone-4 biosynthesis inBacillus subtilis.Enzyme and Microbial Technology. 2020, 141: 109652.

74.Hao Wang, Lin Zhang, Yang Wang, Jianghua Li, Guocheng Du, Zhen Kang. Engineering the heparin-binding pocket to enhance the catalytic efficiency of a thermostable heparinase III fromBacteroides thetaiotaomicron.Enzyme and Microbial Technology. 2020, 137: 109549.

75.Liuyan Gu, Haibo Yuan, Xueqin Lv, Guangsheng Li, Rigang Cong, Jianghua Li, Guocheng Du, Long Liu. High-yield and plasmid-free biocatalytic production of 5-methylpyrazine-2-carboxylic acid by combinatorial genetic elements engineering and genome engineering ofEscherichia coli.Enzyme and Microbial Technology. 2020, 134: 109488.

76.Xueqin Lv, Shixiu Cui, Yang Gu, Jianghua Li, Guocheng Du, Long Liu. Enzyme Assembly for Compartmentalized Metabolic Flux Control.Metabolites.2020, 10(4): 125.

77.Fan Yang, Qiaoling Zhang, Yanfeng Liu, Jianghua Li, Li Wang, Jian Chen. Lactic acid biosynthesis pathways and important genes ofLactobacillus panisL7 isolated from the Chinese liquor brewing microbiome.Food Bioscience. 2020, 36: 100627.

78.Yexu Wu, Yanfeng Liu, Chuanchuan Lu, Senlin Lei, Jianghua Li, Guocheng Du. Quantitation of RNA by a fluorometric method using the SYTO RNASelect stain.Analytical Biochemistry.2020, 113857.

79.Chunmei Chen, Jieying Deng, Xueqin Lv, Jianghua Li, Guocheng Du, Huazhong Li, Long Liu. Biocatalytic synthesis of lactosucrose using a recombinant thermostable β-fructofuranosidase fromArthrobactersp. 10138.Bioengineered.2020, 11(1): 416-427.

80.Taichi Chen, Hongzhi Xia, Shixiu Cui, Xueqin Lv, Xueliang Li, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu. Combinatorial Methylerythritol Phosphate Pathway Engineering and Process Optimization for Increased Menaquinone-7 Synthesis inBacillus subtilis.Journal of Microbiology and Biotechnology. 2020, 30(5): ‏762-769.

81.Chuanchuan Lu, Yanfeng Liu, Jianghua Li, Long Liu, Guocheng Du. Engineering of biosynthesis pathway and NADPH supply for improved L-5-methyltetrahydrofolate production byLactococcus lactis.Journal of Microbiology and Biotechnology. 2020, 606: 113857.

82.Ke Liu, Mengyue Gong, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Biotransformation and chiral resolution of d,l-alanine into pyruvate andd-alanine with a whole-cell biocatalyst expressingl-amino acid deaminase.Biotechnology and Applied Biochemistry.2020, 67(4):‏668-676.

83.Tengfei Niu, Xueqin Lv, Zhenmin Liu, Jianghua Li, Guocheng Du, Long Liu. Synergetic engineering of central carbon and nitrogen metabolism for the production of N-acetylglucosamine inBacillus subtilis.Biotechnology and Applied Biochemistry. 2020, 11(1): 416-427.

84.Angela Lombardi,Lionel Cheruzel,Long Liu. Synthetic and engineered enzymes for biocatalysis and biotransformation.BiotechnologyandApplied Biochemistry. 2020, 67: 4.

85.Xiaolong Zhang, Yanting Cao, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Development and optimization of N-acetylneuraminic acid biosensors inBacillus subtilis.Biotechnology andApplied Biochemistry.2020, 67(4): 693-705.

86.Chen Deng, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Long Liu. Development of a DNA double-strand break-free base editing tool inCorynebacterium glutamicumfor genome editing and metabolic engineering.Metabolic Engineering Communications. 2020，11: e00135.

87.Tanatarov Dinmukhamed, Ziyang Huang, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu. Current advances in design and engineering strategies of industrial enzymes.Systems Microbiology and Biomanufacturing.

88.Jieying Deng, Xueqin Lv, Jianghua Li, Guocheng Du, Jian Chen, Long Liu. Recent advances and challenges in microbial production of human milk oligosaccharides.Systems Microbiology and Biomanufacturing.

89.Rongzhen Tian, Minghu Wang, Jintian Shi, Xiaolong Qin, Haoyu Guo, Xuanjie Jia, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu. Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering inBacillus subtilis.Synthetic and Systems Biotechnology. 2020, 5: 131-136.

90.Yanfeng Liu, Anqi Su, rongzhen Tian, Jianghua Li, long Liu, Guocheng Du. Developing rapid growingBacillus subtilisfor improved biochemical and recombinant protein production.Metabolic Engineering Communications. 2020, 11: 00141.

91.张维娇,金学荣,徐雅晴,李江华,堵国成,康振.枯草芽孢杆菌表达与调控工具相关研究进展.《生物技术通报》. 2020, 4: 26-33.

92.牛腾飞,李江华,堵国成,刘龙,陈坚.微生物法合成N-乙酰氨基葡萄糖及其衍生物的研究进展.《食品与发酵工业》.2020, 1: 274-279.

方向四：

93.Chang Su, Jinsong Gong, Jiufu Qin, Jimeng He, Zhengchuan Zhou, Min Jiang, Zhenghong Xu, Jinsong Shi. Glutathione enables full utilization of wool wastes for keratin production and wastewater decolorization.Journal of Cleaner Production. 2020, 270: 122092.

94.Cheng Li, Li Wang, Zhengxing Chen, Yongfu Li, Juan Li. Facile and green preparation of diverse arabinoxylan hydrogels from wheat bran by combining subcritical water and enzymatic crosslinking.Carbohydrate Polymers.2020, 241, 116317.

95.Ren Wang, Hao Zhang, Zhengxing Chen, Qixin Zhong. Structural basis for the low digestibility of starches recrystallized from side chains of amylopectin modified by amylosucrase to different chain length.Carbohydrate Polymers. 2020, 241, 116352.

96.Jian He, Ren Wang, Wei Feng, Zhengxing Chen, Tao Wang. Design of novel edible hydrocolloids by structural interplays between wheat gluten proteins and soy protein isolates.Food Hydrocolloids. 2020, 100, 105395.

97.Qiong Wang, Mengmeng Xu, Liting Zhao, Feng Wang, Youran Li, Guiyang Shi, Zhongyang Ding. Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial-static culture ofGanoderma lucidum.Microbial Biotechnology. 2020, doi:10.1111/1751-7915.13670.

98.Xingqiao Peng, Li Zhu, Zhihai Wang, Xiaobei Zhan. Enhanced stability of the bactericidal activity of nisin through conjugation with gellan gum.International Journal of Biological Macromolecules. 2020, 148, 525-532.

99.Yanli Lei, Miaosen Wu, Junyi Wang, Hongtao Zhang, Xiaobei Zhan, Zhenglong Sun, Jianrong Wu. Preparation and property of a biantenna macromolecule based on polysialic acid.International Journal of Biological Macromolecules. 2020, 155, 1342-1349.

100.Xingqiao Peng, Li Zhu, Jiayun Guo, Zhenglong Sun, Mingming Zhao, Xiaobei Zhan. Enhancing biocompatibility and neuronal anti-inflammatory activity of polymyxin B through conjugation with gellan gum.International Journal of Biological Macromolecules. 2020, 147, 734-740.

101.Xingqiao Peng, Xingyue Yan, Li Zhu, Yiran Gu, Zhenglong Sun, Xiaobei Zhan. Preparation of polymyxin B-loaded gellan-polylysine polyion complex fibers with high affinity to endotoxin.International Journal of Biological Macromolecules. 2020, 160, 703-710.

102.Jinpeng Ye, Jinsong Gong, Chang Su, Yange Liu, Jinsong Shi. Fabrication and characterization of high molecular keratin based nanofibrous membranes for wound healing.Colloids and surfaces B: Biointerfaces. 2020, 194: 111-158.

103.Chao Chen, Ting Li, Zhengxing Chen, Li Wang, Xiaohu Luo. Absorption Rates and Mechanisms of Avenanthramides in a Caco-2 Cell Model and Their Antioxidant Activity during Absorption.Journal of Agricultural and Food Chemistry. 2020, 68, 2347-2356.

104.Hao Zhang, Ren Wang, Zhengxing Chen, Qixin Zhong. Amylopectin-Sodium Palmitate Complexes as Sustainable Nanohydrogels with Tunable Size and Fractal Dimensions.Journal of Agricultural and Food Chemistry. 2020, 68, 3796-3805.

105.Qi Zhang, Liting Zhao, YouRan Li, Feng Wang, Song Li, Guiyang Shi, Zhongyang Ding. Comparative transcriptomics and transcriptional regulation analysis of enhanced laccase production induced by co-culture ofPleurotus eryngiivar. ferulae withRhodotorula mucilaginosa.Applied Microbiology and Biotechnology. 2020, 104, 241-255.

106.Rongxian Zhang, Jinsong Gong, Chang Su, Jiufu Qin, Heng Li, Hui Li, Jinsong Shi, Zhenghong Xu. Recombinant expression and molecular engineering of the keratinase fromBrevibacillus parabrevisfor dehairing performance.Journal of Biotechnology. 2020, 320: 57.

107.Zhitao Li, Li Zhu, Wenlong Zhang, Xiaobei Zhan, Minjie Gao. New dynamic digestion model reactor that mimics gastrointestinal function.Biochemical Engineering Journal. 2020, 154, 107431.

108.Jinsong Gong, Jinpeng Ye, Liyan Tao, Chang Su, Jinsong Shi. Efficient keratinase expression via promoter engineering strategies for degradation of feather wastes.Enzyme and Microbial Technology. 2020, 137: 109550.

109.Chang Su, Jinsong Gong, Jinpeng Ye, Jimeng He, Ruiyi Li, Min Jiang, Yan Geng, Yan Zhang, Jinghua Chen, Zhenghong Xu, Jinsong Shi. Enzymatic extraction of bioactive and self-assembling wool keratin for biomedical applications.Macromolecular Bioscience. 2020, 20(9): 200007.

110.Yanan Li, Ren Wang, Zhengxing Chen, Xiuping Zhao, Xiaohu Luo, Li Wang, Yongfu Li, Fei Teng. Preparation of magnetic mesoporous silica from rice husk for aflatoxin B1 removal: Optimum process and adsorption mechanism.Plos One. 2020, doi: org/10.1371/journal.pone.0238837.

111.Minjie Gao, Liping Liu, Shan Li, Jiliang Lyu, Yun Jiang, Li Zhu, Xiaobei Zhan, Zhi-Yong Zheng. Multi-stage glucose/pachymaran co-feeding enhanced endo-β-1,3-glucanase production byTrichoderma harzianumvia simultaneous increases in cell concentration and inductive effect.Bioprocess and Biosystems Engineering. 2020, 43, 1479-1486.

112.Shunzhi Wang, Zikai Wang, Jinsong Gong, Jiufu Qin, Tingting Dong, Zhenghong Xu, Jinsong Shi. Improving the biocatalytic performance of co-immobilized cells harboring nitrilase via addition of silica and calcium carbonate.Bioprocess and Biosystems Engineering. 2020, 43: 2201.

113.Zhihong Du, Yulin Li, Xiaohu Luo, Jiali Xing, Qingchuan Zhang, Ren Wang, Li Wang, Zhengxing Chen. Effects of Electron Beam Irradiation on the Physicochemical Properties of Quinoa and Starch Microstructure.Starch-Starke. 2020, 72, 1900178.

114.Xiaopeng Xu, Zuoming Nie, Zhiyong Zheng, Li Zhu, Xiaobei Zhan. Effect of different nitrogen sources on the viscosity and rheological properties of welan gum produced bySphingomonassp. ATCC 31555.Journal of Texture Studies. 2020, 51: 642-649.

115.Xingqiao Peng, Gengliang Liu, Li Zhu, Kejing Yu, Kun Qian, Xiaobei Zhan. In vitro and in vivo study of novel antimicrobial gellan-polylysine polyion complex fibers as suture materials.Carbohydrate Research. 2020, 496, 108115.

116.王子凡,郑志永,高敏杰,李想,詹晓北.装配水平筛板的气升式反应器中气液传质特性的数值模拟.《过程工程学报》. 2020, 1: 20-26.

117.李想,陈瑜琦,王子凡,郑志永,陈海琴,高敏杰,詹晓北.螺旋筛板气升式反应器在真菌发酵中的应用.《食品与发酵工业》.202, 15: 93-99.