【个人简介】

周小满

江南大学 博士后/助理研究员

邮箱：xiaoman@jiangnan.edu.cn

研究方向：糖链解析；肿瘤生物学；唾液酸修饰；蛋白组学

【学术简介】

江南大学生物工程学院/无锡医学院博士后，江南大学本硕博毕业。主要从事于糖蛋白质谱解析和蛋白糖基化修饰生物功能研究。

【研究领域】

1、膀胱癌蛋白糖基化修饰功能解析

2、唾液酸修饰蛋白质谱解析

3、免疫相关分子糖基化修饰功能探究

【主要论著】

[1]Zhou X^#, Zhang J^#, Song Z, Lu S, Yu Y, Tian J, Li X, Guan F. ExoTracker: a low-pH-activatable fluorescent probe for labeling exosomes and monitoring endocytosis and trafficking [J]. Chem Commun (Camb), 2020, 56(94): 14869-14872.

[2]Zhou X, Zhai Y, Liu C, Yang G, Guo J, Li G, Sun C, Qi X, Li X, Guan F. Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin alpha5beta1 interaction and Akt signaling pathway [J]. Cell Commun Signal, 2020, 18(1): 44.

[3]Zhou X, Yang G, Guan F. Biological Functions and Analytical Strategies of Sialic Acids in Tumor [J]. Cells, 2020, 9(2): 273.

[4]Zhou X, Yang S, Yang G, Tan Z, Guan F. Two-step derivatization and mass spectral distinction of α2,3 and α2,6 sialic acid linkages on N-glycans by MALDI-TOF [J]. Chinese Chemical Letters, 2019, 30(3): 676-680.

[5] Tan Z, Cao L, Wu Y, Wang B, Song Z, Yang J, Cheng L, Yang X,Zhou X,Dai Z, Li X, Guan F. Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells [J]. Journal of Extracellular Vesicles, 2020, 10(1): 56-72.

[6] Ma M, Fu Y,Zhou X, Guan F, Wang Y, Li X. Functional roles of fucosylated and O-glycosylated cadherins during carcinogenesis and metastasis [J]. Cell Signal, 2019, 63: 109365.

[7] Guo J, Liu C,Zhou X, Xu X, Deng L, Li X, Guan F. Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells [J]. Int J Mol Sci, 2017, 18(8): 1528.

[8] Lu X, Wang G, Feng Y, Liu S,Zhou X, Du G, Chen J. The N-Terminal alpha-Helix Domain ofPseudomonas aeruginosaLipoxygenase Is Required for Its Soluble Expression in Escherichia coli but Not for Catalysis [J]. J Microbiol Biotechnol, 2016, 26(10): 1701-1707.

[9] Lu X, Liu S, Feng Y, Rao S,Zhou X, Wang M, Du G, Chen J. Enhanced thermal stability of Pseudomonas aeruginosa lipoxygenase through modification of two highly flexible regions [J]. Appl Microbiol Biotechnol, 2014, 98(4): 1663-1669.

[10] Lu X, Liu S, Zhang D,Zhou X, Wang M, Liu Y, Wu J, Du G, Chen J. Enhanced thermal stability and specific activity ofPseudomonas aeruginosalipoxygenase by fusing with self-assembling amphipathic peptides [J]. Appl Microbiol Biotechnol, 2013, 97(21): 9419-9427.