【Study and work experience】

2005.09 -- 2011.06 Nanjing University of Technology, Major in Industrial Biocatalysis, Ph.D

2011.08-2015.08 School of Pharmaceutical Sciences, Jiangnan University, Lecturer

2015.08-2020.12 School of Pharmacy, Jiangnan University, Associate Professor, Master tutor

2018.12-2019.12 Visiting Scholar at Cornell University

2022.01-now Associate Professor, School of Life Science and Health Engineering, Jiangnan University

【Main academic part-time】

Member of Marine Medicine Branch of Jiangsu Pharmaceutical Society and member of Pharmaceutical Society

【Brief introduction of scientific research】

Main research topics in the past 5 years

Research and application on bio-manufacturing and efficacy mechanism of nutritional chemicals such as functional sugars/peptides. Participated in more than 10 national/provincial and ministerial scientific research projects and enterprise technology development projects, published more than 30 papers in domestic and foreign academic journals, authorized more than 20 national invention patents, was invited to participate in the compilation of 2 monographs in Chinese and English, and won 5 science and technology awards.

In the past 5 years, I have presided over the project

[1] National Natural Science Foundation of China, 2023-2026, Hosted;

[2] Subproject of National Key Research and Development Plan, 2021-2024, Preside over;

[3] Subproject of Ningxia Key Research and Development Plan, 2020-2023, preside over;

[4] Jiangsu Province Industry-University-Research Joint Innovation Fund, 2016-2018, presided over.

[Representative Papers in Recent 5 years]

[1]Li H, Ji K, Liu P, Geng Y, Gong JS, Zhang C, Ding ZZ, Xu ZH, Shi JS^*. Chitotriose Enhanced Antitumor Activity of Doxorubicin through Egr1 Upregulation in MDA-MB-231 Cells. Marine Drugs, 2024, 22:26

[2] Liu P,Li H^*, Xu HY, Gong JS, Jiang M, Qian JY, Xu ZH, Shi JS. Chitooligosaccharides Attenuated Hepatic Encephalopathy in Mice through Stabilizing Gut–Liver–Brain Disturbance. Molecular Nutrition & Food Research, 2023, 67(1): 2200158.

[3] Liu P,Li H^*, Li RY, Geng Y, Gong JS, Xu HY, Xu ZH, Shi JS*. Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects. Food Research International, 2022, 157: 1-12.

[4] Liu P,Li H^*, Gong JS, Geng Y, Jiang M, Xu HY, Xu ZH, Shi JS*. Chitooligosaccharides alleviate hepatic fibrosis by regulating the polarization of M1 and M2 macrophages. Food & Function, 2022, 13(2):753-768.

[5] Zheng JLLi H^*, Zhang XJ, Jiang M, Luo CQ, Lu ZM, Xu ZH, Shi JS*. Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of metformin in correlation with modulating gut microbiota. Journal of Agricultural and Food Chemistry, 2018, 23 (66): 5821-5831.

[6] Chen YJ, Dou WF,Li H, Shi JS, Xu ZH^*. The alginate lyase fromIsoptericola halotoleransCGMCC 5336 as a new tool for the production of alginate oligosaccharides with guluronic acid as reducing end. Carbohydrate Research, 2018, 470: 36-41.

[7] LIU Peng, HOU Zhixing, MAO Hongwei,Li Heng^*, GONG Jinsong, Jiang Min, XU Hongyu, XU Zhenghong, Shi Jinsong^*. Effect and mechanism of chito-oligosaccharides on hepatocyte injury induced by hydrogen peroxide.Food Science, 2023, 44(5): 136-142.

[8] Wu Wen, Zhu Fengshuai, YU Jiale,Li Heng^*, Gong Jinsong, Xu Zhenghong, Shi Jinsong.Recombinant expression and modification optimization of algin lyase in halophilic termite bacteria. Food and Fermentation Industry, 2023, 49(2): 47-53.

[9]LI Heng, ZHENG Jialin, YU Haihui, XING Wenhui, LU Zhenming, Jiang Min, ZHANG Xiaojuan, XU Zhenghong, Shi Jinsong^*. Hypoglycemic study and preliminary mechanism analysis of mannooligosaccharides. Science in China: Life Sciences, 2019, 49(5):10.

[10] HAO Yao,LI Heng^*, GONG Jinsong, Jiang Min, XU Zhenghong, Shi Jinsong^*. Construction of recombinant algin lyase expression system and optimization of induction conditions. Journal of Nanjing University of Traditional Chinese Medicine, 2018, 34(3): 227-230; 324.

[Major patents granted in the last 5 years]

[1]LI Heng, WU Yifan, YU Jiale, DING Yizhen, Liu Shun, WU Yanli, ZHENG Kexin, SHI Jinsong, XU Zhenghong. A composition based on brown alga extract and Lactobacillus reuteri and its application, ZL2021106774330 .

[2]Li Heng, Shi Jinsong, Li Xinglin, Wu Wen, Gong Jinsong and Xu Zhenghong. A mutant algin lyase based on loop region modification and its application, ZL2020102600335.

[3]Li Heng, Shi Jinsong, Yang Tao, Gong Jinsong, Xu Zhenghong, Sun Wenjing, Zhou Qiang. Preparation of niacin from composite immobilized gibberella, ZL2013100631894. (in Chinese)

[4]Li Heng, Wang Qisong, Yang Shenggui, Qian Jianying, Shi Jinsong, Xu Zhenghong. A process for clean production of chitin from shrimps and crabs waste biomass by solid-state fermentation with microecological microbial agent, ZL 2013100062573.

[5] Shi Jin-Song,Li Heng, Li Xing-Lin, Wu Wen, Gong Jin-song. A site-mutated algin lyase mutant and its application, ZL2020102451769.

[6] Shi Jin-Song,Li Heng, Ji Ke, Yu Hai-Hui, Geng Yan, Xu Zheng-Hong, Liu Peng, Pu Ting-Lin. [6] A drug composition with antitumor effect, ZL2019105502204.

[7] Shi Jin-Song,Li Heng, Yang Tao, Gong Jin-Song, Xu Zheng-Hong, Sun Wen-Jing, Zhou Qiang. A method for preparing niacin by immobilization of Gibberella and bioconversion, ZL 2012105383720.

[8] Xu Zheng-Hong, Zhu Xiao-Yan,Li Heng, Shi Jin-Song, Gong Jin-Song, Qian Jian-ying, Sun Wen-Jing, Zhou Qiang. [8] A nitrile hydrolase and its gene sequence and application method, ZL 2012104330961.

Major Prize

Science and Technology Awards:

[1] First Prize of Science and Technology, China Business Federation, 2022, ranking 1;

[2] Second Prize of Jiangsu Science and Technology Award, 2020, ranking 5th;

[3] Second Prize of Scientific Research and Technological Invention in Universities of higher Learning, 2019, ranking 4;

[4] First Prize of Science and Technology Progress Award of China Business Federation, 2018, ranking 2;

[5] First Prize of Science and Technology Progress Award of China Business Federation, 2017, ranking 2.

Teaching Award:

[1] First Prize of Jiangsu Graduate Research Innovation Practice Competition, Excellent Instructor Award, 2022, ranking 1;

[2] First Prize Advisor of National College Students Life Science Innovation and Entrepreneurship Competition, 2019, ranking 2;

[3] First Prize Instructor of National College Students Pharmaceutical Engineering Design Competition, 2018, ranking 1;

[4]Second Prize of university-level Teaching Achievement Award, 2017, ranking 2;

[5]Excellent Undergraduate Thesis Advisor of Jiangnan University, 4, 2013-2022.