ShuqinXu, PhD, Associate Professor

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PERSONAL PARTICULARS

Name:Shuqin Xu

Date of birth:02.1986

Nationality:Chinese

Address:School of Life Science and Health Engineering, Jiangnan University, Lihu Av. 1800, Wuxi, China, 214122

Email:sqxu@jiangnan.edu.cn;shuqinxu_2015@163.com

Telephone:18352835391; 0510-85911900

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SUMMARY:

We are interesting in the "green" synthesis and preparation of natural polysaccharides/oligosaccharides, and studying their structure-activity relationship. Combining the knowledge of natural polymer physics, material chemistry and glycobiology, we focus on studying the interaction of biological macromolecules, self-assembly mechanism and the structure-activity mechanism of nerve regeneration regulated by glyco-materials.

EDUCATION:

Ph.D.(2008.9-2013.6),PolymerChemistry& Physics, College of Chemistry andMolecular Sciences, Wuhan University, Wuhan, China. Thesis mentor:Prof. Lina Zhang. (Academician of Chinese Academy of Science)

B.E. (2004.9-2008.6), Polymer Materials and Engineering, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, China

PROFESSIONALEXPERIENCE:

Jan 2022 - Associate Professor, Jiangnan University, School of Life Science and Health Engineering

Jun 2018 - Dec 2021 Associate Professor, Jiangnan University, School of Pharmaceutical

Jul 2015 - May 2018 Lecturer, Jiangnan University, School of Pharmaceutical

Dec 2013 - Dec 2014 Post Doctoral Fellow,Chemical Biology and Medicinal Chemistry,Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Advisor:Dr. Jian Liu. (John A. and Deborah S. McNeill, Jr. Distinguished Professor)

GRANT AWARDS:

1. Chondroitin Sulfate Mimicked Assembly and Dynamic Network Synergize to Promote Neural Regeneration. NSFC No. 22278180, 2023-2026, 540,000, (PI: Shuqin Xu).

2. Study on controllable synthesis of chondroitin sulfate and its mechanism of regulating neural regeneration mediated by RPTP signaling. The Fellowship of China Postdoctoral Science Foundation No. 2022M711364, 2021-2022, 80,000, (PI: Shuqin Xu).

3. Enzymatic synthesis of Chondroitin sulfate oligosaccharides and its mechanism of regulating nerve regeneration by RPTP signaling. Jiangsu Postdoctoral Research Funding Program No. 2021K412C, 2021-2022, 20,000, (PI: Shuqin Xu).

4. Studies on the chemoenzymatic synthesis, chain structures and anti-inflammation activity of chondroitin sulfate derivatives. NSFC No. 21604033, 2017-2019, 200,000, (PI: Shuqin Xu).

PUBLICATIONS:

1. X. Tang, Z. Wang, M. Wang, S. Zhou, J. Chen, S. Xu*, Nanoarchitectonics of cellulose nanocrystal conjugated with a tetrasaccharide-glycoprobe for targeting oligodendrocyte pre

2. S. Xu*, H. Xiang, Z. Wang, X. Tang, Y. Zhang, X. Zhan, J. Chen*, Conjugation of a phenanthrene-imidazole fluorophore with the chondroitin sulfate generated from E. coli K4 poly

3. S. Xu*, S. Zhou, B. Mao, J. Chen*, Z. Zhang, Cornea-stroma-mimicking films derived from cellulose nanocrystal templating fibrous collagen as therapeutic contact lenses. ACS Su

4. S. Xu*, M. Qiu, Q. Zhang, J. Wu, H. Xiang, J. Chen*, Chain structure and immunomodulatory activity of a fructosylated chondroitin from an engineered Escherichia coli K4. Internas. Carbohydrate Polymers, 2023, 317, 121086.

5. Q. Zhang, R. Yao, X. Chen, L. Liu, S. Xu, J. Chen, J. Wu*, Enhancing fructosylated chondroitin production in Escherichia coli K4 by balancing the UDP precursors. Metabolic Engineerinaccharide. Journal of Applied Polymer Science, 2021, 138: e51538.

6. S. Xu, X. Zhang, B. Duan, J. Chen*, An engineered platform based on chitin-affinity immobilization for producing low molecular weight heparin. Carbohydrate Polymers, 2017, 177, ustainable Chemistry & Engineering, 2019, 7(14): 12248-12260.

7. S. Xu, M. Qiu, X. Zhang, J. Chen*, Expression and characterization of an enhanced recombinant heparinase I with chitin binding domain. International Journal of Biological macromnational Journal of Biological Macromolecules, 2019, 133: 702-711.

8. S. Xu, X. Xu, M. Xu, T. R. O’Leary, L. Zhang*, Heat-induced conformation transition of the comb-branched β-glucan in dimethyl sulfoxide/water mixture. Carbohydrate Polymers, 2017, 157, 1404-1412.47, 314-322.

9. Y. Xu, A.F. Moon, S. Xu, J.M. Krahn, J. Liu*, L. C. Pedersen, Structure based substrate specificity analysis of heparan sulfate 6-O-sulfotransferases. ACS Chemical Biology, 2017, 12, 73-8297-305.

10. S. Xu, Z. Ping, X. Xu*, L. Zhang*, Changes in shape and size of the stiff branched beta-glucan in dimethlysulfoxide/water solutions. Carbohydrate Polymers, 2016, 138, 86-93.romolecules, 2017, 105, 1250-1258.

11. L. Yu, S. Xu, C. Deng, H. Li, Q. Yang, Z. Xu, J. Chen*, Preparation and partial structural characterization of the exopolysaccharide from Bacillus mucilaginosus SM-01. Carbohyd7, 1404-1412.

12. S. Xu, Y. Lin, J. Huang, Z. Li, X. Xu*, L. Zhang*, Construction of High Strength Hollow Fibers by Self-assembly of the Stiff Polysaccharide with Short Branches in Water. Journal of M-82.

13. S. Xu, X. Xu, L. Zhang*, Effect of Heating on Chain Conformation of Branched β-Glucan in Water. J. Phys. Chem. B, 2013, 117, 8370-8377.

14. S. Xu, X. Xu*, L. Zhang*, Branching Structure and Chain Conformation of Water-Soluble Glucan Extracted from Auricularia Auricula-Judae. J. Agric. Food Chem., 2012, 60, 3498-3506.yd. Polym. 2016, 146, 217–223.

15. S. Li, S. Xu, L. Zhang*, Advances in Conformations and Characterizations of Fungi Polysaccharides. Acta Polymerica Sinica, 2010, 12, 1359-1375.nal of Materials Chemistry A, 2013, 1, 4198-4206. Hot Paper.

16. S. Chen, Y. Yuan, L. Pan, S. Xu, et al. A Novel Supramolecular Plaster Based on an Organic Acid-base Compound: Synthesis, Structure, Mechanical Properties, and Sterilizing Pe

PATENTS:

1. S. Xu, M. Wang, Z. Wang, J. Chen. Chondroitin oligosaccharides synthesized via click chemistry and preparation method thereof. CN2023106157725

2. S. Xu, X. Tang, J. Chen, M. Gong. The preparation method of multi-responsive neural scaffold material and application thereof. ZL2022106879303.

3. S. Xu, Z. Wang, X. Tang, M. Wang, G. Wang, J. Chen. Fluorescent oligosaccharide marker, a preparation method and application thereof. ZL2022104039490.

4. S. Xu, X. Tang, Z. Wang, J. Shi, J. Chen. Responsive cellulose nanocrystal and preparation method thereof. ZL202210391304X.

5. S. Xu, Z. Wang, M. Wang, J. Chen. Non-animal chondroitin sulfate oligosaccharide and preparation method thereof. ZL202110983725.7.

6. J. Chen, S. Xu, B. Mao. Purification method for bovine type I collagen protein. ZL2021106856631.

7. S. Xu, B. Mao, J. Chen. Preparation method of oriented micro-patterned conductive film and application thereof. ZL202110608754.5.

8. S. Xu, J. Chen, B. Mao. Nanomaterial of polyglycerol grafted cellulose nanocrystal dendrimer and preparation method thereof. US 11760843 B2.

9. S. Xu, B. Mao, J. Chen. Nanomaterial of polyglycerol grafted cellulose nanocrystal dendrimer and preparation method thereof. ZL202110013564.9

10. S. Xu, S. Zhou, L. Liang, J. Chen. Preparation method of dialdehyde cellulose nanocrystalline whisker. ZL201711274555.5.

11. L. Zhang, S. Xu, X. Xu. A Water-soluble Polysaccharide Extracted from Auricularia Auricular-judae and Preparation Method Thereof. ZL201210060695.3.

MEETING ABSTRACTS:

1.Shuqin Xu.The construction of arod-like nanoparticleconjugatedwith sugar probesfortargeting OPCs.The5th NationalYouthForumon Glycoscience, Hangzhou, China, Nov 2023, Oral presentation.

2.Shuqin Xu.Study on surface modification of cellulose nanocrystals and its application in nerve regeneration.PolymerSymposiumof China, Wuhan, China, Oct 2023, Oral presentation.

3.Shuqin Xu, Xiaoli Tang, Zhuqun Wang, Liyuan Liang, Meiling Qiu, Baoliang Mao, Jinghua Chen.Synthesis ofchondroitin sulfate and its structure-activity relationship in regulating nerve regeneration. 2023 National Conference of Glycobiology , Wuhan, China, May 2023, Poster.

4.Shuqin Xu.Construction of cellulose nanocrystalline based hydrogels and their application in nerve repair.The13th NationalSymposiumforCharacterization of Polymer Molecule & Structure, Shenzhen, China, Apr 2023, Oral presentation.

5.Shuqin Xu.Study on the construction of micropatterned conductive membrane and its promotion of neural tissue repair. The 2nd National Symposium on Cellulose , Wuhan, China, Oct 2021, Oral presentation.

6.Shuqin Xu, Shuyu Zhou, Baoliang Mao, Jinghua Chen, Ziyin Zhang.Cellulose nanocrystals/collagen multilayers mimic corneal stroma and are used for ophthalmic drug delivery.PolymerSymposiumof China, Xi’an, China, Oct 2019, Poster.

7.Shuqin Xu.Study on the structure and chain conformation of fructochondroitin produced by E. coli K4.The11th NationalSymposiumforCharacterization of Polymer Molecule & Structure. Wuhan, China, Oct 2018, Oral presentation.

8.Shuqin Xu.An engineered platform based on chitin-affinity immobilization for producing low molecular weight heparin.Sino-German Symposium on Polysaccharides: New Chemistry and Materials. Guangzhou, China, Sep 2017, Oral presentation.

9.Shuqin Xu.An engineered platform based on chitin-affinity immobilization for efficiency producing low molecular weight heparin.The 2nd International Symposium for Advanced Gel Materials & Soft Matters,Guiyang, China, Aug 2017,Oral presentation.

10.Shuqin Xu, Lina Zhang.Effect of heating on the conformation of short branched β-glucan in DMSO/ water.PolymerSymposiumof China,Soochow, China, Oct 2015, Poster.

11.Shuqin Xu, Lina Zhang.Effect of heating on the conformation of comb chain polysaccharides in water.PolymerSymposiumof China,Shanghai, China,Oct2013, Poster.

12.Shuqin Xu, Lina Zhang. Chain Conformation Transition of Comb-branched Polysaccharide with Stiff Chain Conformation.The8th NationalSymposiumforCharacterization of Polymer Molecule & Structure,Soochow, China,2012, Excellent poster.

13.Lina Zhang,Shuqin Xu, Xiaojuan Xu, Yi Lin, Jing Huang, Zhen Li. Characterization for Structure and Properties of Comb-branched Polysaccharide with Stiff Chain Conformation. The8th NationalSymposiumforCharacterization of Polymer Molecule & Structure, Soochow, China, 2012,Invitedpresentation.

14.Zhaohua Ping,Shuqin Xu, Lina Zhang. Structure Characterization of Water-soluble Auricularia Auricular-judae Polysaccharide.The8th NationalSymposiumforCharacterization of Polymer Molecule & Structure, Soochow, China, 2012, Poster.

15.Shuqin Xu, Lina Zhang. Self-orientation Behaviors of Comb-branched Polysaccharide with Stiff Chain Conformation.PolymerSymposiumof China, Dalian, China, 2011, Poster.

16.Shuqin Xu, Lina Zhang. Structures and Chain Conformations of a Neutral Auricularia Auricular-judae Polysaccharide.The7th NationalSymposiumforCharacterization of Polymer Molecule & Structure, Shanghai, China, 2010, Excellent poster.

HONORS:

1.Thesis Title: Construction of Cellulose Nanocrystal-Based Stimuli-Responsive Materials and Their Use in Remyelination Research.Exellent Master’s Thesisin Jiangsu Province 2023, Xiaoli Tang (Master Student),Shuqin Xu(Thesis Mentor).

2. Thesis Title: Research on Construction of Micro-patterned Conductive Film and Its Promotion of Neural Repair.Exellent Master’s Thesis in Jiangnan University 2022, Baoliang Mao (Master Student),Shuqin Xu(Thesis Mentor).

3.Shuqin Xu(7th).The key technology and application of microbial fermentation to produce acid functional polysaccharide.Science and Technology Progress Award of China Light Industry Federation, Second Prize, 2019.

4.Shuqin Xu(7th).Key technology and application of acid functional polysaccharide fermentation production and structure control.Science and Technology Progress Award ofMinistry of Education, Second Prize,2019.

5.Shuqin Xu(6th).Key techniques for the preparation of linear glycosaminoglycans by microorganisms and their structure regulation.Science and Technology Award ofChina Federation of Commerce,First Prize,2018.