Current position
Jiangnan University
Associate Professor, School of Life Sciences and Heath Engineering
Postgraduate Training and Fellowship Appointments
The Wistar Institute of Anatomy and Biology
Post-doctoral Fellow,Immunology and Biochemistry, 2016, 8 -
Education
East China University of Science and Technology, Shanghai, P. R. China
Ph. D. Applied Chemistry, 2016
M. S. Applied Chemistry, 2013
B. S. Organic Chemistry, 2011
Research Experience
Dr. Shao's research focuses on photochemistry and biomedicine. The lab has been conducting innovative research in the field of building up fluorescent tools for bioorthogonal labeling of proteins of interest and controlled release and targeted therapy of fluorescent drugs. We have accumulated theoretical knowledge and sufficient scientific skills in the use of aggregation induced fluorescence (AIE) for biological imaging, as well as in the construction of fusion proteins for studying protein interactions and high-throughput drug screening.
Publication List
ØJournal Papers
[1]Yu Jiang, Runqi Li, Fei Ren, Shuke Yang, andAndong Shao, Coumarin-Conjugated Macromolecular Probe for Sequential Stimuli-Mediated Activation,Bioconjug. Chem.,2024,35, 72-79.
[2]Shuke Yang, Liang-Hua Zou, Runqi Li, Yu Jiang, Fei Ren, andAndong Shao, Construction of Coumarin-Based Bioorthogonal Macromolecular Probes for Photoactivation,ACS Appl. Mater. Interfaces,2023,15, 52128–52136.
[3]Fei Ren, Wendi Zhu, Shuke Yang, Chun Zhang, Yingchao Hou, Runqi Li, Jian Wen, Liang-Hua Zou, Min Gao, Wen-Long Wang, Zhihong Wu, andAndong Shao, Coumarin-Based Fluorescent Inhibitors for Photocontrollable Bioactivation,Mol. Pharm.,2023,20, 3223–3233.
[4]Andong Shao, Qin Xu, Chang Won Kang, Christopher F. Cain, Avery C. Lee, Chih-Hang Anthony Tang, Juan R. Del Valle, and Chih-Chi Andrew Hu, IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy,Mol. Pharm.,2022,19, 1059–1067.
[5]Andong Shao, Walker T. Spalek, Qin Xu, Christopher F. Cain, Chih-Hang Anthony Tang, Juan R. Del Valle, Chih-Chi Andrew Hu, Development of Tumor-specific IRE-1 Inhibitors for B cell Cancer Therapy,Mol. Cancer Ther.,2020,19, 2432-2444.
[6]Andong Shao, Chang Won Kang, Chih-Hang Anthony Tang, Christopher F. Cain, Qin Xu, Claire M. Phoumyvong, Juan R. Del Valle, Chih-Chi Andrew Hu, Structural Tailoring of a Novel Fluorescent IRE‑1 RNase Inhibitor to Precisely Control Its Activity,J. Med. Chem.,2019,62, 5404-5413.
[7]Yan Tang,Andong Shao (Co-first author), Jun Cao, Hui Li, Qiang Li, Meiying Zeng, Ming Liu, Yingsheng Cheng, Weihong Zhu, cNGR-based Synergistic-targeted NIR Fluorescent Probe for Tracing and Bioimaging of Pancreatic Ductal Adenocarcinoma,Science China Chemistry,2018,61, 184.
[8]Meiying Zeng,Andong Shao (Co-first author), Hui Li, Yan Tang, Qiang Li, Zhiqian Guo, Chungen Wu, Yingsheng Cheng, He Tian, Weihong Zhu, Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis,ACS Applied Materials&Interfaces,2017,9, 13029.
[9]Yongsheng Li,Andong Shao(Co-first author),Yao Wang, Ju Mei, Dechao Niu, Jinlou Gu, Ping Shi, Weihong Zhu, He Tian, Jianlin Shi, Morphology Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor-Targeted Bioimaging,Adv. Mater.,2016,28, 3187.
[10]Andong Shao, Yongshu Xie, Shaojia Zhu, Zhiqian, Guo, Shiqin Zhu, Jin Guo, Ping Shi, Tony D. James, He Tian, Weihong Zhu, Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects,Angew. Chem. Int. Ed.2015,54, 7275.
[11]Andong Shao,Zhiqian, Guo, Shaojia Zhu, Shiqin Zhu, Ping Shi, He Tian, Weihong Zhu, Insight into Aggregation-induced Emission Characteristics of Red-emissive Quinolinemalononitrile by Cell Tracking and Real-time Trypsin Detection,Chem. Sci.2014,5, 1383.
[12]Si Yao,Andong Shao(Co-first author), Wenru Zhao, Shaojia Zhu, Ping Shi, Zhiqian, Guo, Weihong Zhu, Jianlin Shi, Fabrication of Mesoporous Silica Nanoparticles Hybridised with Fluorescent AIE-active Quinoline-malononitrile for Drug Delivery and Bioimaging,RSC Adv.,2014,4, 58976.
[13]Zhiqian Guo,Andong Shao, Weihong Zhu, Long Wavelength AIEgen of Quinolone-malononitrile,J. Mater. Chem. C,2016,4, 2640.
[14]Xumeng Wu,Andong Shao, Weihong Zhu,A Novel Colorimetric and Ratiometric NIR Fluorescent Sensor for GSH Based on Dicyanomethylene-4H-pyran in Living Cells,Sci. China Chem.,2016,59, 62.
[15]Zhiqing Xia,Andong Shao, Qiang Li, Shiqin Zhu, Weihong Zhu, Substituent Effect on Quinoline-Malononitrile AIE Fluorescent Properties,Acta Chim. Sinica,2016,74, 351.
[16]Tingting Yang, Zhiqian Guo,Andong Shao, Ping Zhao, Weihong Zhu. A Turn-On Fluorescent Probe for Cysteine Based on Benzopyran.Chinese Journal of Applied Chemistry,2016,33, 397.
[17]Mingwei Wang, Nan Yang, Zhiqian Guo, Kaizhi Gu,Andong Shao, Weihong Zhu, Yisheng Xu, Jie Wang, Robert K. Prud’homme, Xuhong Guo, Facile Preparation of AIE-active Fluorescent Nanoparticles through Flash Nanoprecipitation,Industrial & Engineering Chemistry Research,2015, 54,4683.
ØConference Papers
[1]Andong Shao, Zhiqian, Guo, Weihong Zhu, He Tian, The 4thInternational Conference on Molecular Sensors and Molecular Logic Gates, Shanghai,2014. 11. 9-12.
[2]Andong Shao, Weihong Zhu, He Tian, The 1stInternational Conference on Nanomedicine and Nanobiotechnology, Hangzhou,2015. 4. 6-9.
[3]Andong Shao, Zhiqian, Guo, Weihong Zhu, The 2ndInternational Symposium on AIE, Guangzhou,2015. 5. 15-18.
[4]Andong Shao,Chih-Hang Anthony Tang, Chang Won Kang, Juan R. Del Valle, Chih-Chi Andrew Hu,The 36thNational Medicinal Chemistry Symposium,2018. 4. 29.
ØBook Chapter
Andong Shao, Xumeng Wu, Weihong Zhu, Near-infrared Nanomaterials: Preparation, Bioimaging and Therapy Applications (Chapter 5) [M], London,Royal Society of Chemistry,2016.
ØPatents
[1]Weihong Zhu, Chuanxing Shi, Zhiqian Guo, Shiqin Zhu,Andong Shao, Aggregation Induced Emission Based on Quinoline-malononitrile Derivatives, Patent Number: ZL201210199278.7
[2]Weihong Zhu, Zhiqian Guo,Andong Shao, Nitrogen-containing Heterocyclic Compounds and Its Applications, Patent Number:ZL201410512468.9
Personal Information
Address: 1800 Lihu Road, Wuxi, P. R. China Post Code: 214122
Phone: 18221372885 E-mail:adshao@126.com
