Position

Professor

Academic degree

Doctorate

Graduate school

Jiangnan university

Telephone

Research Orientation

Microbial Pharmaceutics

Personal experiences

Education

2003.3-2006.6Jiangnan universityPh.Dwith the subject of fermentation engineering.

1989.9-1992.7 Shenyang pharmaceutical collegeM.E.with the subject of pharmaceutical chemistry.

1985.9-1989.7 Shenyang pharmaceutical collegeB.E.with the subject of pharmaceutical chemistry.

Scientific Career

2021-Now School of Life Science and Health Engineering,Jiangnan universityProfessor

-in charge of converting sucrose to L-serine and its derivativewith recombinant strain.

2006.6-2021 School of Pharmaceutical,Jiangnan universityAssociateProfessor

-in charge of converting sucrose (glycerol) to L-serine with recombinant strain.

1996.5-2003.3 Sino American Shanghai SquibbSupervisor

-in charge of marketing

1992.8-1996.5 Wuxi Pharmaceutical InstituteEngineer

-in charge of new drug synthesis

Scientific research activities

Recent Publications

[1] Yujie Gao, Xiaomei Zhang*, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi and Zhenghong Xu*.

L-serine production byCorynebacterium glutamicumbased on novel insights into L-serine exporters.Biotechnol J, 2023,202300136

[2] Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi and Zhenghong Xu*. Rational metabolic engineering combined with biosensor-mediated Adaptive Laboratory Evolution for L-cysteine overproduction from glycerol inEscherichia coli. Fermentation, 2022, 8:299

[3] Xiaomei Zhang, Yujie Gao, Zi wei chen, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Mattheos A. G. Koffas*, Zhenghong Xu*. High-yield production of L-serine through a novel identified exporter combined with synthetic pathway inCorynebacterium glutamicum, Microb. Cell Fact,2020,19, (1):115

[4] Xiaomei Zhang, Yujie Gao, Ling Yang, Yi Yang, Ping Zheng,i chen,Jibin, Jinsong Shi, Zhenghong Xu*.Amino acid exporters and metabolic modification ofCorynebacterium glutamicum-a reviewChinese Journal of Biotechnology, 2020 36(11): 2250-2259

[5] Xiaomei Zhang,Lianhe Lai, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Mattheos A. G. Koffas*, Zhenghong Xu*. Rewiring the central metabolic pathway for high-yield L-serine production inCorynebacterium glutamicumby using glucose, Biotechnol J, 2019,1800497

[6] Xiaomei Zhang#, Guoqiang Xu#, Jinsong Shi, Mattheos A. G. Koffas*, Zhenghong Xu*. Microbial production of L-serine from renewable feedstocks.Trends Biotechnol, 2018, 36 (7): 700-712

[7] Xin Zhang, Xiaomei Zhang*, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Zhenghong Xu*, Integration of ARTP mutagenesis with biosensor-mediated high-throughput screening to improve L-serine yield inCorynebacterium glutamicum. Appl Microbiol Biotechnol,2018,102:5939-5951

[8] Guoqiang Xu, Qinjian Zhu, Yuchang Luo, Xiaojuan Zhang, Wen Guo, wenfang Dou, Hui LI, Hongyu Xu,Xiaomei Zhang*, Zhenghong Xu*, Enhanced production of L-serine by deletingsdaA combined with modifying and overexpressingserAin a mutant ofCorynebacterium glutamicumSYPS-062 from sucrose.Biochem Eng J, 2017, (118) :113-122

[9] Xiaomei Zhang, Lianhe Lai, Guoqiang Xu, Xiaojuan Zhang, Jinsong Shi, Zhenghong Xu*. Effects of pyruvate kinase on the growth ofCorynebacterium glutamicumand L-serine accumulation.Process Biochem, 2017, 55:32-40

Recent projects

[1] National Natural Science Foundation of China [32171470]

[2] National KeyResearch and Development Program of China[2018YFA0901400]

[3] National KeyResearch and Development Program of China[2018YFA0900303]

[4]Enterprise project [181345]

Engineering Background

Has undertaken or participated in several industrial collaboration projects, while parts of the achievements have been applied to commercial production.

Teachingactivities

Teaching Courses

Undergraduate courses:《Pharmaceutical Technology》

《Pharmaceutical Administration and Regulation》

Postgraduate courses:《New Techniques in Pharmacy》

Professional direction

Microbiological and Biochemical Pharmacy

Supervising of Postgraduate Students: 1-2 per year;

Supervising of Undergraduate Students: 3-4 per year.

Updated: March2024