Basic Information

Title: Professor

Affiliation: School of Life Science and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu Province, China

Email address: gengyan@jiangnan.edu.cn; gengyanjnu@163.com

Education

Ph.D., Biology,Nanjing University, 2011

• Define the role of Fstl1 in the lung development using Fstl1-KO mice as a model.

• Define the role of Fstl1 on the Idiopathic pulmonary fibrosis.

B.A., Biotechnology (Biochemical pharmacy),Nanjing University, 2006

Research and Professional Experiences

06/2011 - 10/2014Lecturer, School of Pharmaceutical Sciences, Jiangnan University

10/2014 - 06/2021Associate professor in Biomedical Engineering

School of Pharmaceutical Sciences, Jiangnan University

06/2021 - 12/2021Professor, School of Pharmaceutical Sciences, Jiangnan University

01/2022 - Present Professor,School of Life Science and Health engineering, Jiangnan University

·To define the role ofDesulfovibrioin the liver fibrosis.

·To define the role ofStenotrophomonasin lung fibrosis.

·To screen and isolate the anti-fibrotic components/compounds.

08/2015 -12/2017Postdoctal in Department of Medicine, Cedars-Sinai Medical Center, USA

Advisor: Paul Nobel and Dianhua Jiang

·To define the role of invasive lung fibroblast in the idiopathic lung fibrosis (IPF).

·To define the role ofbeta-Arrestinin the IPF.

Grant Activity

2020-2023 National Natural Science Foundation of China (No. 31970746), “Mechanism ofDesulfovibrio desulfuricansinducing liver fibrosis through the gut-liver axis”, Role: PI

2018-2021 National Natural Science Foundation of China (No. 31771514), “The role of Fstl1 in cell fate determination of hepatic stellate cells during the progression and resolution of liver fibrosis”, Role: PI

Publications within five years

[1]Duan W, Zhou L, Ren Y, Liu F, Xue Y, Wang F Z, Lu R, Zhang X J, Shi J S, Xu Z H#,Geng Y#. Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice [J]. Food Funct, 2024, 15(3): 1612-1626.

[2]Nie Y, Xie X-Q, Zhou L, Guan Q, Ren Y, Mao Y, Shi J-S, Xu Z-H,Geng Y. Desulfovibrio fairfieldensis-Derived Outer Membrane Vesicles Damage Epithelial Barrier and Induce Inflammation and Pyroptosis in Macrophages [J]. Cells, 2023, 12(1): 89.

[3]Lu G, Zhang Y, Ren Y, Shi J-S, Xu Z-H,Geng Y. Diversity and Comparison of Intestinal Desulfovibrio in Patients with Liver Cirrhosis and Healthy People [J]. Microorganisms, 2023, 11(2): 276.

[4]Yang T, Guan Q, Shi J-S, Xu Z-H#,Geng Y#. Metformin alleviates liver fibrosis in mice by enriching Lactobacillus sp. MF-1 in the gut microbiota [J]. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, 1869(5): 166664.

[5]Duan W, Guan Q, Zhang H-L, Wang F-Z, Lu R, Li D-M,Geng Y#, Xu Z-H#. Improving flavor, bioactivity, and changing metabolic profiles of goji juice by selected lactic acid bacteria fermentation [J]. Food Chemistry, 2023, 408:135155.

[6]Shen J, Ni Y, Guan Q, Li R, Cao H,Geng Y#, You Q#. Stenotrophomonas maltophilia promotes lung adenocarcinoma progression by upregulating histone deacetylase 5 [J]. Front Microbiol, 2023, 14: 1121863.

[7]Ren Y#, Sun Q, Gao R, Sheng Y, Guan T, Li W, Zhou L, Liu C, Li H, Lu Z, Yu L, Shi J, Xu Z, Xue Y#,Geng Y#. Low Weight Polysaccharide of Hericium erinaceus Ameliorates Colitis via Inhibiting the NLRP3 Inflammasome Activation in Association with Gut Microbiota Modulation [J]. Nutrients, 2023, 15(3): 739.

[8]Liu F, Duan W, Guan T, Zhou Q, Yan W,Geng Y#. Water extract of Pingchuan formula ameliorated murine asthma through modulating metabolites and gut microbiota [J]. J Pharm Biomed Anal, 2023, 236:115728.

[9]Guan T, Li S, Guan Q, Shi J S, Lu Z M, Xu Z H,Geng Y#. Spore Powder of Paecilomyces hepiali Shapes Gut Microbiota to Relieve Exercise-Induced Fatigue in Mice [J]. Nutrients, 2022, 14(14): 2973.

[10]Liu X*,Geng Y*, Liang J, Coelho A L, Yao C, Deng N, Wang Y, Dai K, Huang G, Xie T, Liu N, Rowan S C, Taghavifar F, Kulur V, Liu Z, Stripp B R, Hogaboam C M, Jiang D, Noble P W. HER2 drives lung fibrosis by activating a metastatic cancer signature in invasive lung fibroblasts [J]. J Exp Med, 2022, 219(10): e20220126.

[11]Xu X Y,Geng Y#, Xu H X, Ren Y, Liu D Y, Mao Y#. Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways [J]. Front Mol Biosci, 2022, 9:835508.

[12]Guo L, Guan Q, Duan W, Ren Y, Zhang X J, Xu H Y, Shi J S, Wang F Z, Lu R, Zhang H L, Xu Z H#, Li H#,Geng Y#. Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake [J]. Front Nutr, 2022, 9:929776.

[13]Geng Y, Yue Y, Guan Q, Ren Y, Guo L, Fan Y, Lu Z M, Shi J S, Xu Z H. Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il-10 Deficient Mice [J]. Mol Nutr Food Res, 2021, 65(24): e2001227.

[14]Xie X Q,Geng Y#, Guan Q, Ren Y, Guo L, Lv Q, Lu Z M, Shi J S, Xu Z H. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study [J]. Nutrients, 2021, 13(3): 1008

[15]Ren Y, Li H X, Zhou L, Lu Z M, Shi J,Geng Y#, Xu Z H. Protective Effect of Spore Powder of Antrodia camphorata ATCC 200183 on CCl4-Induced Liver Fibrosis in Mice [J]. Nutrients, 2020, 12(9): 2778.

[16]Xu X Y, Du Y, Liu X, Ren Y, Dong Y, Xu H Y, Shi J S, Jiang D, Xu X, Li L, Xu Z H,Geng Y#. Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-beta1-miR29a in mice [J]. Cell Commun Signal, 2020, 18(1): 151.

[17]Jing F,Geng Y#, Xu X Y, Xu H Y, Shi J S, Xu Z H#. MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H(+) Transporting V1 Subunit C1 [J]. Int J Mol Sci, 2019, 20(4): 796.

[18]Geng Y, Liu X, Liang J, Habiel D M, Vrishika K, Coelho A L, Deng N, Xie T, Wang Y, Liu N, Huang G, Kurkciyan A, Liu Z, Tang J, Hogaboam C M, Jiang D, Noble P W. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis [J]. JCI Insight, 2019 ;4(6):e125326.

Teaching Assignments

2018 - present Pharmacology, Cell Biology and Immunology for Undergraduates, Jiangnan University