Prof.Zengwei Laiwas born in 1984 in Sanming, Fujian province, China, and received his BSc in chemistry from Hebei Normal University in 2008. He obtained his PhD from China Pharmaceutical University and Shanghai Institute of Organic Chemistry (SIOC) in 2014 under the supervision of Prof. Hongbin Sun and Prof. Shu-Li You before doing postdoctoral studies with Prof. Jianwei Sun at The Hong Kong University of Science and Technology.
Education and Research Experience:
2004.9-2008.7 Hebei Normal University, B.Sc.
2008.9-2011.7 Yunnan University-Kunming Institute of Botany, M.Sc.
2011.9-2014.7 China Pharmaceutical Universityand Shanghai Institute of Organic Chemistry (SIOC), Ph.D.
2014.8-2016.1 Hong Kong University of Science and Technology, Post-doct.
2016.2-2018.12 National Sun Yat-sen University-Second Military Medical University
2019.1-2022.2 Shanghai Institute of Medicine
2022.3- present School of Life Sciences and Health Engineering, Jiangnan University
Research Interests
1. Developing novel drugs based on natural products: discovery of novel compounds from natural products for total synthesis and targeted structural optimization of novel molecules. In recent years, a number of lead compound with pharmaceutical properties have been discovered, for the treatment of major chronic diseases such as diabetes, chronic Obstructive lung disease and pulmonary hypertension.
2. Developing efficient new methods of organic synthesis to construct diverse drug-like molecular entities (heterocyclic compound), and then screening for their activities to aid in the discovery of drug leaders.
Publications:
1.Xiao You, Kai-Wen Hu, Haonan Zong, Xiaoan Wen, Haoliang Yuan, Keguang Cheng*, Qing-Long Xu *,Zengwei Lai*. Synthesis of polycyclic fused oxazolidin-2-ones by catalytic Boron(III)-Promoted oxo-Michael addition reaction and evaluation on their cytotoxicity.Tetrahedron2023,149, 133714.
2. Kai-Long Ji, Wei Liu, Wei-Hang Yin, Xiang-Rong Kong, Hong-Hong Xua,Zeng-Wei Lai*, Jing-Ya Li*, Jian-Min Yue*. A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study,Acta Pharmaceutica Sinica B,2023,13(8), 3414-3415.
3.Kai-Wen Hu,Xiao You,Xiaoan Wen,Haoliang Yuan,* Qing-Long Xu,*Zengwei Lai*.Synthesis of Functionalized Thiazolidin-2-imine and Oxazolidin-2-one Derivatives from p-Quinamines via [3 + 2] Annulation of Isothiocyanates and CO2.J. Org. Chem.2023, 88, 5052-5058.
4.Kai-Wen Hu,Xiao You,Jin-Zheng Wang,Xiaoan Wen,Hongbin Sun,* Qing-Long Xu,*,Zengwei Lai*.Chiral Phosphoric Acid Catalyzed Asymmetric Desymmetrization ofpara-Quinamines with Isocyanates: Access to Functionalized Imidazolidin-2-one Derivatives.Org. Lett.2021,23(20), 7873-7877.
5.Zengwei Lai,Renwei Zhang, Qiang Feng, Jianwei Sun*.3-Aminooxetanes: Versatile 1,3-Amphoteric Molecules for Intermolecular Annulation Reactions.Chem. Sci.2020,11, 9945-9949.
6.ianhua Zhang#,Zengwei Lai#,Shuyin Yuan, Yi-You Huang, Guoqiang Dong, Chunquan Sheng*, Hengming Ke*, Hai-Bin Luo*. Discovery ofEvodiamine Derivativesas Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.J. Med. Chem.2020, 63,17, 9828-9837. (#:equal contribution)
7.Chen Zhang, Qian Zhou, Xu-Nian Wu, Ya-Dan Huang, Jie Zhou,Zengwei Lai*, Yinnuo Wu*, Hai-Bin Luo. Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease.J. Enzym. Inhib. Med. Chem.2018,33(1), 260-270.
8.Zeng-Wei Lai, Chuan Liu, Hongbin Sun*, Shu-Li You*. Asymmetric Synthesis of 3-Allyloxindoles and 3-Allenyloxindoles by Scandium(III)-catalyzed Claisen Rearrangement Reactions.Chin. J. Chem.2017,35(10), 1512-1516.
9.Zengwei Lai, Zhaobin Wang, Jianwei Sun*. Organocatalytic Asymmetric Nucleophilic Addition to ortho-Quinone Methides by Alcohols.Org. Lett.2015,17(24), 6058-6061.
10.Zeng-Wei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Discovery of Highly Potent DPP-4 Inhibitors by Hybrid Compound Design Based on Linagliptin and Alogliptin.Eur. J. Med. Chem.2014,83, 547-560.
11.Yu-Rong Yang*,Zeng-Wei Lai, Liang Shen, Jiu-Zhong Huang, Xing-De Wu, Jun-Lin Yin and Kun Wei. Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction.Org. Lett.2010,12(15), 3430-3433.
Contact information:
School of Life Science and Health Engineering, Jiangnan University, 1800 Lihu Avenue, Wuxi City, Jiangsu Province, China
Phone: (+86) 19519910389
E-mail: 2860879@sina.com
